PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores
By P. Bickel, J. Tansey, Michael A. Welte. Biochimica et Biophysica Acta, 2009
688 citations recorded by the source corpus.
Summary The PAT family of lipid droplet proteins includes 5 members in mammals: perilipin, adipose differentiation-related protein (ADRP), tail-interacting protein of 47 kiloDaltons (TIP47), S3-12, and OXPAT. Members of this family are also present in evolutionarily distant organisms, including insects, slime molds and fungi. All PAT proteins share sequence similarity and the ability to bind intracellular lipid droplets, either constitutively or in response to metabolic stimuli, such as increased lipid flux into or out of lipid droplets. Positioned at the lipid droplet surface, PAT proteins manage access of other proteins (lipases) to the lipid esters within the lipid droplet core and can interact with cellular machinery important for lipid droplet biogenesis. Genetic variations in the gene for the best characterized of the mammalian PAT proteins, perilipin, have been associated with metabolic phenotypes, including type 2 diabetes mellitus and obesity. In this review, we discuss how the PAT proteins regulate cellular lipid metabolism both in mammals and in model organisms.
Subfields: Biochemistry, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/be616d2c62b8192ebd9b513d5113bd5e31277a10
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Citations in the corpus
- INSECT FAT BODY: ENERGY, METABOLISM, AND REGULATION (2010, background): “Overexpression and deletion of Lsd2 in Drosophila lead to an increase and a reduction of the triglyceride content, respectively (56,119).”
- Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila (2015, neutral): “In Drosophila, lipid droplets in adipose tissue (known as fat body) express the regulatory protein Lsd-2 (perilipin-2) on their surface (Bickel et al., 2009; Kühnlein, 2011), and we find that this is also the case for droplets in the CNS (Figure 2C).”
- Lipolysis – A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores (2011, background): “Perilipin-1 is a member of the PAT family (for review see [105]).”