Non Alcoholic Fatty Liver Disease, Hepatic Insulin Resistance and Type 2 Diabetes

By Andreas L. Birkenfeld, Gerald I. Shulman. Hepatology, 2014

698 citations recorded by the source corpus.

Nonalcoholic fatty liver disease (NAFLD), hepatic insulin resistance, and type 2 diabetes are all strongly associated and are all reaching epidemic proportions. Whether there is a causal link between NAFLD and hepatic insulin resistance is controversial. This review will discuss recent studies in both humans and animal models of NAFLD that have implicated increases in hepatic diacylglycerol (DAG) content leading to activation of novel protein kinase Cϵ (PKCϵ) resulting in decreased insulin signaling in the pathogenesis of NAFLD‐associated hepatic insulin resistance and type 2 diabetes. The DAG‐PKCϵ hypothesis can explain the occurrence of hepatic insulin resistance observed in most cases of NAFLD associated with obesity, lipodystrophy, and type 2 diabetes. (Hepatology 2014;59:713‐723)

Subfields: Cardiology and Cardiovascular Medicine, Endocrinology, Diabetes and Metabolism, Epidemiology

View Paper: https://www.semanticscholar.org/paper/c0906b91195c3e0734a5f8b66d925611d6276cd5

Citations in the corpus

• Triglyceride metabolism in the liver (2017, neutral): “It is associated with obesity, type 2 diabetes and dyslipidemia, and commonly occurs in the setting of insulin resistance (22).”