Non‐coding RNAs: the architects of eukaryotic complexity

By John S. Mattick. EMBO Reports, 2001

864 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2503ef5a656eee74c41314848c1e0546789f334b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Increasing biological complexity is positively correlated with the relative genome-wide expansion of non-protein-coding DNA sequences (2003, neutral): “to create alternate gene products via alternate splicing, regulation of gene expression, and the ability to generate new proteins by exon shuffling [40], as well by their potential ability to transmit RNA signals into the system [34, 35].”
Non‐coding RNAs: regulators of disease (2010, background): “These findings have directly challenged the traditional view of RNA as simply an intermediary between DNA and protein, and imply that the vast majority of the genome — long regarded as ‘junk’ - encodes functional RNA species that orchestrate the development of complex organisms [11,12].”
The functional role of long non-coding RNA in human carcinomas (2011, background): “NcRNAs are loosely grouped into two major classes based on transcript size; small ncRNAs and lncRNAs (Table 1) [28-30].”
The many faces of the helix-turn-helix domain: transcription regulation and beyond. (2005, background): “Additionally, the eukaryotes might also extensively employ post-transcriptional control mechanisms, involving regulatory RNAs, resulting in a lower dependence on transcriptional regulators [175,176].”
A comprehensive comparison of comparative RNA structure prediction approaches (2004, background): “Surprisingly, the number of protein coding genes does not correlate with our concept of "organism complexity", hence it has been hypothesised that control of gene expression via a combination of alternative splicing and non-coding RNAs are responsible for this, implying that the "Central Dogma" (RNA”
Is prokaryotic complexity limited by accelerated growth inregulatory overhead? (2003, background): “Given that noncoding RNA accounts for about 97% of all transcriptional output in humans [28], and that many complex genetic phenomena in higher organisms are RNA-directed [29], it seems likely that RNA (which is utilized only for a few specific functions in prokaryotes) has been coopted by the eukar”
Non-coding RNA. (2006, background): “Moreover, only a minority of the genomes of multicellular organisms is occupied by protein-coding sequences, the proportion of which declines with increasing complexity, with a concomitant increase in the amount of non-coding intergenic and intronic sequences, most of which are in fact transcribed [”
Genome-wide transcription and the implications for genomic organization (2007, methodology): “Below we discuss the possible advantages of using RNA-based regulatory systems, of the sort envisioned by Mattic”
GENCODE: producing a reference annotation for ENCODE (2006, background): “However, in the past four years there has been an explosion in the discovery of transcripts with no apparent coding potential (termed non-coding RNAs) and there are indications these could play as important a role in cellular function as proteins [2,3].”
Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs. (2004, background): “However, groups of transcripts similar to an RNA-based signaling network model (Mattick, 2001).the apparent absence of negative correlation in the ex- pression levels of coding-noncoding pairs suggests that The human genome has tens of thousands of noncoding transcripts, and as a general class,…”
Phenotypic plasticity: linking molecular mechanisms with evolutionary outcomes (2002, background): “Methylation of DNA is a mechanism used widely across eukaryotes (Mattick, 2001).”
RNA regulation: a new genetics? (2004, background): “I examine what is required to programme complex objects and explain the logic behind my previously published hypothesis that the main output of the genomes of complex organisms is genetically active but non-coding RNA (ncRNA”