The complement system in regulation of adaptive immunity

By M. Carroll. Nature Immunology, 2004

1,086 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/24caadeb194a5bee69bb2c8b1a4a6cd4f00b038f

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Citations in the corpus

The complement system: an unexpected role in synaptic pruning during development and disease. (2012, background): “Emerging evidence implicates microglia In the immune system, the activated C3 fragment C3b (iC3b) opsonizes the surface of cells/debris and tags them for elimination by phagocytic macrophages that express C3 receptors (C3R/cd11b) (Carroll 2004, Gasque 2004, van Lookeren Campagne et al. 2007).”
Overview of the Immune Response (2003, background): “The complement system is composed of more than 25 plasma and cell-surface proteins that include 3 activation pathways (Fig 9) and soluble and membrane-bound downmodulating regulatory pathways.(97,98) Many of the proteins of the activation pathway are proteinases, and activation occurs in a cascade b”
Modulation of the anti-tumor immune response by complement (2008, background): “Complement's wide-ranging activities link the innate immune response to the subsequent activation of adaptive immunit”
Exploiting lymphatic transport and complement activation in nanoparticle vaccines (2007, background): “Complement primarily serves as a biochemical defense system that clears pathogens nonspecifically, but it can also play a role in promoting antigen-specific immune response”
Complement regulators and inhibitory proteins (2009, background): “Complement activation in turn activates pro-inflammatory mediators, generates anaphylactic peptides, cytolytic compounds and antimicrobial compounds, recruits effector cells and induces effector response”
The role of complement in inflammatory diseases from behind the scenes into the spotlight. (2007, background): “The inadequacy of this “complementary” concept becomes apparent in light of recent studies demonstrating functions of complement that are essential and “central” to the innate immune response, as well as functions that bridge innate with adaptive immunity.(2) Today, complement should rather be viewe”
Pattern recognition receptors and control of adaptive immunity (2009, background): “For example, attachment of theC3dg fragment to an antigen ‘flags’ the antigen as foreign, or microbial, and directs efficient antibody responses against the antigen (9).”
Recent advances in the innate immunity of invertebrate animals. (2005, neutral): “6) (Fujita, 2002, Caroll, 2004).”
Interactions between the immune and nervous systems in pain (2010, background): “The complement system is an important part of the innate defens”
The Role of Microglia in the Healthy Brain (2011, background): “This summary is not meant to be a comprehensive review of microglia physiology, but rather to share new results and stimulate further research into the cellular and molecular mechanisms by which microglia influence postnatal development, adult neuronal plasticity, and circuit function.”
The Role of the Anaphylatoxins in Health and Disease (2009, neutral): “Veerhuis R, Van Breemen MJ, Hoozemans JM, Morbin M, Ouladhadj J, Tagliavini F, Eikelenboom P. Amyloid beta plaque-associated proteins C1q and SAP enhance the Abeta(1-42)peptide-induced cytokine secretion by adult human microglia in vitro.”