Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF

By M. Guilliams, I. D. de Kleer, S. Henri, S. Post, L. Vanhoutte, Sofie De Prijck, K. Deswarte, B. Malissen, H. Hammad, B. Lambrecht. Journal of Experimental Medicine, 2013

1,162 citations recorded by the source corpus.

Alveolar macrophages differentiate from fetal monocytes in a GM-CSF–dependent fashion and colonize the alveolar space within a few days after birth.

Subfields: Immunology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/7a3e5273fd592ea2936846c1aef36fe0f3238175

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. P. Italiani
2. D. Boraschi
3. A. Mildner
4. Florent Ginhoux
5. Steffen Jung
6. C. Varol
7. V. Bronte
8. S. Yona

In Pulmonary and Respiratory Medicine

1. S. Gordon

Citations in the corpus

• SARS-CoV-2 infection: The role of cytokines in COVID-19 disease (2020, neutral): “The main sources of this biomolecule are fibroblasts and endothelial, epithelial, stromal, and hematopoietic cells [164], and it is secreted by epithelial cells in the lung [173,174].”
• Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation (2014, background): “01), and by gating directly on these engrafted lung macrophages, we observed reduced FLT3-driven recombination, consistent with their fetal-liver monocyte origin (Figure S5B) (Guilliams et al., 2013).”
• Macrophages: development and tissue specialization. (2015, background): “Moreover, adult lung alveolar macrophages were shown to originate from fetal liver monocytes in a CSF-2 (GM-CSF)-governed pathway (40).”
• Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span (2017, background): “Extending the findings from several groups (Guilliams et al., 2013; Hashimoto et al., 2013; van de Laar et al., 2016), we found that TR-AMs were remarkably stable, constituting >95% of alveolar macrophages at 14 mo of age (Fig.”
• The fate and lifespan of human monocyte subsets in steady state and systemic inflammation (2017, background): “It is now recognized that the majority of tissue macrophage populations are seeded before birth (Ginhoux et al., 2010; Schulz et al., 2012; Guilliams et al., 2013; Hashimoto et al., 2013; Yona et al., 2013; Mass et al., 2016) and maintained via self-proliferation throughout adulthood with minimal…”
• Macrophage heterogeneity in tissues: phenotypic diversity and functions (2014, background): “(37) have shown that alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GMCSF.”