Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo

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Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells. (2011, neutral): “5) state (the ground state) (Nichols et al., 2009; Ying et al., 2008); (2) ESCs form PGCs within a few days when introduced into the blastocysts; and (3) in the continuous presence of Activin A (ActA) and basic fibroblast growth factor (bFGF), ESCs convert into EpiSC-like cells exhibiting…”
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. (2010, background): “This block in PE formation by FGF inhibition is supported by another recent study (Nichols et al., 2009).”
Nanog Is the Gateway to the Pluripotent Ground State (2009, positive): “…produced in the absence of Nanog we examined responsiveness to 2i. Culture of early embryos in 2i maximizes expansion of the epiblast (Nichols et al., 2009a) and facilitates subsequent derivation of ES cells, including from otherwise recalcitrant strains (Nichols et al., 2009b; Ying et al., 2008).”
FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst (2010, background): “Intrinsic and extrinsic variations (noise) in individual cells determine whether cells can respond to the signal (Nijhout, 2004; Raj and van Oudenaarden, 2008; Huang, 2009).”