Inactivation of peroxiredoxin I by phosphorylation allows localized H(2)O(2) accumulation for cell signaling.
By H. Woo, S. Yim, D. Shin, D. Kang, Dae-Yeul Yu, S. Rhee. Cell, 2010
618 citations recorded by the source corpus.
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/21fece0a9198fa96aa9b617b12d199a1088f6763
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
- Navdeep S. Chandel
- B. Dickinson
- Christopher J. Chang
- C. Winterbourn
- S. Rhee
- Barry Halliwell
- B. Kalyanaraman
In Molecular Biology
- Navdeep S. Chandel
- Lucas B. Sullivan
- M. Murphy
- B. Dickinson
- Christopher J. Chang
- Barry Halliwell
- P. Schumacker
- C. Winterbourn
Citations in the corpus
- Chemistry and biology of reactive oxygen species in signaling or stress responses (2011, background): “A second example of localized redox buffer control has been identified recently, in which the Prx1 isoform, which is substantially less susceptible to overoxidation than its Prx2 congener, can be selectively deactivated by phosphorylation in cells stimulated with growth factors or in mice during cut”
- ROS-dependent signal transduction (2014, background): “An example of this mechanism, which involves inactivation of membrane-associated PRX1 and growth factor stimulated NOX-induced H2O2, has recently been described in mammalian cells [30].”
- Mitochondrial reactive oxygen species and cancer (2014, background): “This results in localized accumulation of hydrogen peroxide and increased growth factor signaling [23].”
- Hydrogen peroxide sensing, signaling and regulation of transcription factors (2014, background): “of peroxiredoxin activity by its phosphorylation [ 50 , 15 ] ( Fig.”
- Cellular mechanisms and physiological consequences of redox-dependent signalling (2014, neutral): “PtdInsP 3 , phosphatidylinositol (3,4,5)-trisphosphate; SH, thiol; SOH, sulphenic acid.”
- Unravelling the Biological Roles of Reactive Oxygen Species (2011, background): “Such regulation may provide a means of generating favorable gradients of hydrogen peroxide around the appropriate location at the right time for signaling in response to stimulation of cell surface receptors (Woo et al., 2010).”