Unravelling the Biological Roles of Reactive Oxygen Species

By M. Murphy, A. Holmgren, N. Larsson, Barry Halliwell, Christopher J. Chang, B. Kalyanaraman, S. Rhee, Paul J Thornalley, Linda Partridge, D. Gems and 4 more. Cell Metabolism, 2011

748 citations recorded by the source corpus.

Summary Reactive oxygen species are not only harmful agents that cause oxidative damage in pathologies, they also have important roles as regulatory agents in a range of biological phenomena. The relatively recent development of this more nuanced view presents a challenge to the biomedical research community on how best to assess the significance of reactive oxygen species and oxidative damage in biological systems. Considerable progress is being made in addressing these issues and here we survey some recent developments for those contemplating research in this area.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/633edb7fb5780f40816cd4e70a6610929c006f61

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Citations in the corpus

ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease (2020, background): “At physiological concentrations, ROS are vital secondary messengers in multiple cellular processes, including inflammation, cellular growth and differentiation [136,137].”
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents (2020, background): “Insults to the CNS, such as accumulation of protein aggregates associated with neurodegenerative diseases, cause upregulation of NOX activity and oxidant generation — involving both neurons and microglia (the main phagocytes in the brain that serve as neuron supporting cells).”
13 reasons why the brain is susceptible to oxidative stress (2018, background): “susceptible to oxidative stress is because reactive species play useful biological roles [19,20].”
Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. (2012, background): “As pointed out in a recent review [3], reactive oxygen and nitrogen species are not single entities but represent a broad range of chemically distinct reactive species with diverse biological reactivities [3,4].”
The Basics of Thiols and Cysteines in Redox Biology and Chemistry (2014, background): “With the enhancement in chemical probes and methodologies for detecting not only protein oxidation, but also the small molecule oxidants that cause the oxidation of proteins [26, 27], the stage is set for rapid expansion of our knowledge of detailed mechanisms involved in redox regulation and sensin”