Indirect activation of naïve CD4+ T cells by dendritic cell–derived exosomes

By C. Théry, Livine Duban, É. Segura, P. Véron, O. Lantz, S. Amigorena. Nature Immunology, 2002

960 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/21f99721f195d7ee43812f11bfc76f129e4148be

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. C. Théry
2. G. Raposo
3. Marina Colombo
4. J. Schorey
5. O. Joffre
6. M. Nolte
7. R. Spörri
8. C. Reis e Sousa

In Molecular Biology

1. G. Raposo
2. C. Théry
3. Raghu Kalluri
4. Marina Colombo
5. X. Breakefield
6. Guillaume van Niel
7. J. Schorey
8. Prachi Singh

Citations in the corpus

• Extracellular Vesicles: Unique Intercellular Delivery Vehicles. (2017, background): “(B7-1) and CD86 (B7-2) [72] or directly by ICAM-1-presenting mature DC-derived EVs [73].”
• Exosomes: secreted vesicles and intercellular communications (2011, background): “The information transferred could include antigens or MHC–peptide complexes for increasing the range of antigen-presenting cells and the efficiency of induction of immune responses [13-15], or in some cases negative signals leading to death of the target cell [16].”
• The biology and function of exosomes in cancer. (2016, background): “Early studies elucidating the biological functions of exosomes have implicated them in the regulation of adaptive immunity (3, 54).”
• Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses (2011, background): “By contrast, exosomes must be captured by DCs to activate naïve T lymphocytes: these DCs themselves do not necessarily express the right MHC molecules, but can present the exosomal MHC–peptide complexes to specific T cells (46,47).”
• Exosomes: a common pathway for a specialized function. (2006, background): “DC-derived exosomes appear to mediate transfer of MHC class II-peptide complexes to an ‘‘intermediate’’ recipient cell, such as a neighbouring DC, then able to activate CD4+T cells in an antigen specific manner (48).”
• Exosomes are released by cultured cortical neurones. (2006, methodology): “The density and size of these vesicles are compatible with those described for exosomes purified from other cells (Thery et al., 2002a,b).”