Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
By Javier A. Menéndez, R. Lupu. Nature Reviews. Cancer, 2007
2,822 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/21b6f4bcee9f65ad27aada66049f9a59eb028bca
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
- M. V. Vander Heiden
- David M. Sabatini
- Craig B. Thompson
- Sophia Y. Lunt
- E. White
- Joshua D. Rabinowitz
- A. Schulze
- Huafeng Zhang
In Molecular Biology
- David M. Sabatini
- M. V. Vander Heiden
- E. White
- M. Laplante
- Craig B. Thompson
- R. Shaw
- Roberto Zoncu
- Sophia Y. Lunt
Citations in the corpus
- Targeting cancer metabolism: a therapeutic window opens (2011, background): “Many cancer cells rely on de novo fatty acid synthesis to generate new membranes for cell growth, and the enzymes that are directly involved in fatty acid synthesis have been suggested as cancer target”
- Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity (2020, background): “This is associated with glycolysis as the glycolytic pathway supplies the energy and fuel required for FA synthesis [165].”
- Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness (2014, background): “Ce lated in human malignancies and plays important roles in cancer pathogenesis (Menendez and Lupu, 2007; Migita et al., 2009).”
- Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression (2015, background): “The expression of FASN is overexpressed in many types of cancers, and high expression and activity of FASN provide a survival advantage in cancer cells [89].”
- Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications (2017, background): “…although most normal cells use dietary or fatty tissue-derived FA that circulate in the bloodstream either as FFA bound to albumin or as part of lipoproteins, most cancer cells de novo synthetize their FA independently from nutrient availability and hormone stimulation (Menendez and Lupu, 2007).”
- Cancer cell metabolism: Warburg and beyond. (2008, background): “Fatty acid synthase, expressed at low levels in normal tissues, is upregulated in cancer and may also be required for tumorigenesis (reviewed in Menendez and Lupu, 2007).”
- mTOR: from growth signal integration to cancer, diabetes and ageing (2010, background): “mTORC1 indirectly upregulates the enzyme fatty acid synthase (FAS), a transcriptional target of SREBP1 involved in lipid biogenesis that favours the rapid proliferation of cancer cells (reviewed in Ref”
- Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis (2010, background): “Heightened lipogenesis is an established early hallmark of dysregulated metabolism and pathogenicity in cancer (Menendez and Lupu, 2007).”
- Lipid metabolism reprogramming and its potential targets in cancer (2018, background): “Lipogenesis is strongly up-regulated in human cancers to satisfy the demands of increased membrane biogenesis [7, 8, 21, 23].”
- Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids (2013, background): “Finally, Akt induces lipogenesis through mechanisms including enzyme phosphorylation and transcriptional activation, like mTOR-dependent activation of SREBP1 (5, 6).”