Targeting cancer metabolism: a therapeutic window opens
By M. V. Vander Heiden. Nature reviews. Drug discovery, 2011
1,380 citations recorded by the source corpus.
Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical evidence has linked cell metabolism with cancer outcomes. Together, these observations have raised interest in targeting metabolic enzymes for cancer therapy, but they have also raised concerns that these therapies would have unacceptable effects on normal cells. However, some of the first cancer therapies that were developed target the specific metabolic needs of cancer cells and remain effective agents in the clinic today. Research into how changes in cell metabolism promote tumour growth has accelerated in recent years. This has refocused efforts to target metabolic dependencies of cancer cells as a selective anticancer strategy.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/a581182fedb11b34b5cd3cf82b63c8984c515c36
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In Cancer Research
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Citations in the corpus
- Cancer Cell Metabolism: One Hallmark, Many Faces (2012, background): “As this matter has been addressed and given excellent detailed commentaries in a number of recent reviews (19, 20, 71), we will describe a few key issues here and again briefly revisit the topic in later sections.”
- Understanding the intersections between metabolism and cancer biology (2017, neutral): “Exposing patients to high levels of 2-deoxyglucose generated tumor responses but caused hypoglycemia symptoms, and more tolerable doses in modern trials have been disappointing (Vander Heiden, 2011).”