Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

By Jurre J. Kamphorst, J. Cross, Jing Fan, E. de Stanchina, Robin Mathew, E. White, Craig B. Thompson, Joshua D. Rabinowitz. Proceedings of the National Academy of Sciences of the United States of America, 2013

682 citations recorded by the source corpus.

Subfields: Biochemistry, Cancer Research

View Paper: https://www.semanticscholar.org/paper/682615d64e5925c6c006041016476dec08407d84

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In Biochemistry

In Cancer Research

Citations in the corpus

From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy (2016, background): “BPTES inhibition of hGA(124-551), a truncated form of human kidneytype glutaminase.”
An Updated Review of Lysophosphatidylcholine Metabolism in Human Diseases (2019, background): “In addition, findings from a lipid consumption study also suggested that LPC provides a more accessible nutrient source for cell proliferation under hypoxia [136].”
KRAS: feeding pancreatic cancer proliferation (2014, neutral): “This scavenging phenotype may be a general property of Ras-driven cancers as Ras transformed cells were recently shown to scavenge extracellular lipids as a critical aspect of their metabolism[71].”
Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development (2013, background): “More recently, a study showed that hypoxic cancer cells take up lysophospholipids to fulfil their demand for unsaturated FAs (Kamphorst et al., 2013).”
Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation. (2014, background): “Several previous works observed that hypoxia was associated with a dependency on extracellular FA and a reduction in de novo FA synthesis (Kamphorst et al., 2013; Young et al., 2013).”
Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila (2015, neutral): “This study reveals an antioxidant role for lipid droplets that could be relevant in many different biological contexts.”
Regulation of mammalian nucleotide metabolism and biosynthesis (2015, background): “However, hypoxic cells also ferment glucose to lactate, producing 2 ATP/mol glucose and in cancer cells glycolysis is typically accelerated many fold (42,121–122), which may produce ATP at a rate comparable to the more efficient mitochondrial oxidation of fuels including fatty acids (104,123), Gln (”
Glutaminolysis: A Hallmark of Cancer Metabolism. (2017, background): “Extracellular Glutamine Sources Ras-transformed cells can scavenge unsaturated fatty acids from extracellular lysophospholipids, resulting in levels of intracellular fatty acids that are fourfold higher than in cells in a lysophospholipid-free medium (134).”