The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development.

By J. Fata, Y. Kong, Ji Li, Takehiko Sasaki, J. Irie-Sasaki, R. Moorehead, R. Elliott, S. Scully, E. Voura, D. Lacey and 3 more. Cell, 2000

776 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/2130c153cf67207c67bc7bb29ad7610bfb320b4e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Bharat B. Aggarwal
2. S. Khosla
3. F. Greten
4. L. Xing
5. B. Boyce
6. R. Baron
7. Xu Feng
8. M. Karin

In Oncology

1. M. Karin
2. Bharat B. Aggarwal
3. F. Greten
4. S. Khosla
5. Xu Feng
6. J. McDonald
7. L. Xing
8. Hiroshi Takayanagi

In Rheumatology

1. Bharat B. Aggarwal
2. Hiroshi Takayanagi

Citations in the corpus

• Biology of RANK, RANKL, and osteoprotegerin (2007, background): “RANK protein expression has been reported in mammary gland [ 21 ] and some cancer cells, including breast and prostate cancers [22,25], two types of tumors with high bone metastasis potential.”
• NF-κB in cancer: from innocent bystander to major culprit (2002, background): “RANKL is produced by mammary epithelial cells during pregnancy in response to hormonal stimuli and acts in an autocrine manner through its receptor RANK, which is also expressed in the mammary epitheliu”
• Essential Role for ADAM19 in Cardiovascular Morphogenesis (2004, background): “Furthermore, overexpression of ADAM19 increases ectodomain release of tumor necrosis factor-related activation-induced cytokine (TRANCE, also referred to as osteoprotegerin-ligand [OPGL]) (7), a protein with important roles in osteoclast differentiation, dendritic cell survival, and mammary gland de”
• Minireview: the OPG/RANKL/RANK system. (2001, background): “In particular, they fail to form lobulo-alveolar structures during pregnancy, resulting in death of the newborns (26).”
• The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling. (2004, background): “An unexpected finding is that these mice had important mammary gland development deficiency, resulting in death of the newborns [37].”
• Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease. (2008, neutral): “The other significant extraskeletal manifestation of total RANK/ RANKL ablation in knockout mice was a defect in mammary gland development during pregnancy and lactation (73).”
• Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems (2007, background): “(a lack of lymph nodes and abnormality in the spleen) and mammary gland”
• Osteoblast-Osteoclast Interactions (2017, background): “membrane of osteoclast progenitor, mature osteoclasts, dendritic cells and mammary glands (31).”
• Signalling pathways of the TNF superfamily: a double-edged sword (2003, methodology): “Further evidence comes from gene-deletion studies, which showed marked OSTEOPETROSIS after the deletion of either RANK or RANK”