Minireview: the OPG/RANKL/RANK system.

By S. Khosla. Endocrinology, 2001

1,531 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Orthopedics and Sports Medicine

View Paper: https://www.semanticscholar.org/paper/eedbd21edfd4c221424281c1f92426223aaac5db

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. M. Zaidi
2. Jay J Cao
3. E. Eriksen
4. D. Lacey
5. Osbjorn M. Pearson
6. S. Goodman
7. Zhenyu Yao
8. D. Lieberman

In Oncology

1. M. Zaidi
2. Jay J Cao
3. E. Eriksen
4. D. Lacey
5. Osbjorn M. Pearson
6. D. Lieberman
7. W. J. Boyle
8. W. S. Simonet

In Orthopedics and Sports Medicine

1. M. Zaidi
2. Jay J Cao
3. E. Eriksen
4. D. Lacey
5. Osbjorn M. Pearson
6. D. Lieberman
7. W. J. Boyle
8. W. S. Simonet

Citations in the corpus

• Effects of obesity on bone metabolism (2011, background): “These proinflammatory cytokines are capable of stimulating osteoclast activity through the regulation of the RANKL/RANK/OPG pathway [49,50].”
• Inflammation, Fracture and Bone Repair (2016, background): “When exposed to RANKL, these precursor cells fuse and develop the functions of active osteoclasts [77].”
• Silk fibroin as biomaterial for bone tissue engineering. (2016, background): “Their differentiation and function is controlled by 5 osteoprotegerin, receptor activator of nuclear factor (NF)-kappaB (RANK) and RANK ligand (RANKL) [20].”
• Cellular mechanisms of bone remodeling (2010, background): “Osteoclast differentiation is also modulated by M-CSF [26].”
• IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology. (2004, background): “OPG, which is synthesized as a protein of 401 aminoacids, is cleaved to give a 380 amino-acids mature protein [6].”
• TSH is a negative regulator of skeletal remodeling. (2003, background): “TSH inhibited CFU-F and CFU-OB colony formation in a con-mains and the subsequent activation of Akt, MAP ki- nases (JNK, ERK, and p38) and NF B (Khosla, 2001; centration-dependent manner (Figures 7A and 7B).”
• Osteoclast differentiation and activation (2003, background): “Recent breakthroughs in our understanding of osteoclast differentiation and activation have come from the analysis of a family of biologically related tumour necrosis factor (TNF) receptor (TNFR)/TNF-like proteins: osteoprotegerin (OPG), receptor activator of nuclear factor (NF)-κB (RANK) and RANK l”
• The aging of Wolff's "law": ontogeny and responses to mechanical loading in cortical bone. (2004, background): “Consequently, the ratio of OPG-L/RANKL to OPG/RANK may be an important determinant of bone remodeling activity (Khosla, 2001).”