Essential Role for ADAM19 in Cardiovascular Morphogenesis

By Hong-Ming Zhou, G. Weskamp, V. Chesneau, U. Şahin, A. Vortkamp, K. Horiuchi, R. Chiusaroli, Rebecca T. Hahn, D. Wilkes, P. Fisher and 5 more. 2004

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Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands (2004, methodology): “…5, 2004 dition to adam9/12/15 / triple knockout and adam9/12/15/17 / quadruple knockout mice, we also used adam17 / (Peschon et al., 1998) and adam19 / (Zhou et al., 2004) mice as well as wild-type controls of mixed genetic background (129Sv/C57Bl6) to generate the corresponding primary mEF cells.”
A Disintegrin and Metalloprotease (ADAM): Historical Overview of Their Functions (2016, background): “In addition, ADAM-19 is important for heart development as 80% of ADAM-19 deficient animals die postnatally from congenital heart defects [90].”
Deficits in spatial learning and motor coordination in ADAM11-deficient mice (2006, background): “For example, ADAM10, ADAM17 and ADAM19 are critical for normal development by providing growth signals at the correct times and places [3-6].”
Metalloprotease‐disintegrin ADAM8: Expression analysis and targeted deletion in mice (2005, background): “ADAM15 has a role in pathological neovascularization in mice (Horiuchi et al., 2003), whereas ADAM19 is essential for cardiovascular morphogenesis (Kurohara et al., 2004; Zhou et al., 2004).”