circRNA biogenesis competes with pre-mRNA splicing.

By Reut Ashwal-Fluss, M. Meyer, N. Pamudurti, Andranik Ivanov, Osnat Bartok, M. Hanan, Naveh Evantal, Sebastian Memczak, Nikolaus Rajewsky, Sebastian Kadener. Molecules and Cells, 2014

2,779 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/203e3eca1879c1dcd494fa90835e8011b44e3499

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

Citations in the corpus

CSCD: a database for cancer-specific circular RNAs (2017, background): “Modulation of splicing factor muscleblind (MBL) levels affects circMBL biosynthesis, revealing the competition between regular splicing and circularization (16).”
Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes (2016, background): “Moreover, circRNAs were reported to be associated to the pre-mRNA splicing [8], and therefore, most of circRNAs were generated from protein coding genes [39].”
Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development (2015, background): “There is increasing evidence that circular RNA is involved in biochemical pathways, including acting as miRNA sponges [2, 7] and binding proteins [2, 40].”
Circular RNA Expression: Its Potential Regulation and Function (2016, background): “In the fly brain, the abundant circRNA from thembl gene autoregulates levels of the MBL protein and also binds, and is sequestered by, the circRNA isoform [11].”
Circular RNAs: diversity of form and function (2014, methodology): “Circular RNA constructs have been engineered both in vitro and in vivo using group I permuted intron–exon (PIE) sequences (Puttaraju and Been 1992; Ford and Ares 1994; Perriman and Ares 1998), by including complementary sequences in the sequences flanking spliceosomal backsplice sites (Pasman et al.”
Regulation of circRNA biogenesis (2015, background): “Recent studies have uncovered that the processing of circRNAs is not only catalyzed by canonical spliceosomal machinery,(23,30) but also regulated as canonical splicing by both cis-elements(12,18,23,31) and transfactors.(23,29) Given the discrete expression of circRNAs, additional cis-/transregulato”
Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma. (2018, background): “derived from pre-mRNAs,[10, 11, 27, 43] and circRNAs could be regulated by RNA-binding proteins [12, 43-46] post-transcriptionally, we assumed that cSMARCA5, but not mSMARCA5, was regulated by certain RNA-binding proteins post-transcriptionally in human HCC development.”
CircRNA: functions and properties of a novel potential biomarker for cancer (2017, background): “More circRNA functions were also found, such as acting as scaffolds in the assembly of protein complexes [3], sequestering proteins from their native subcellular localization [4], modulating the expression of parental genes [5–8], regulating alternative splicing [9] and RNA–protein interactions [10]”
Circular RNAs: Promising Biomarkers for Human Diseases (2018, background): “CircRNAs are mainly synthesized by the transcription of proteincoding genes with RNA polymerase II (Pol II); but unlike linear RNAs, they are not produced by canonical mode of RNA splicing [5].”
Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function (2017, background): “Backsplicing is context-dependent (4, 7), and circRNAs are often tissue- and developmental stage–specifically expressed (3).”
Circular RNA and its mechanisms in disease: From the bench to the clinic. (2018, background): “RBP pairing (Ashwal-Fluss et al., 2014; Conn et al., 2015) and intron pairing (Lee & Rio, 2015; Rybak-Wolf et al., 2015; Zhang et al., 2014) drive circularization in the direct back-splicing pathway of circRNA formation.”