Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

By Monika Piwecka, Petar Glažar, L. Hernandez-Miranda, Sebastian Memczak, S. Wolf, A. Rybak-Wolf, Andrei Filipchyk, F. Klironomos, Cledi Alicia Cerda Jara, Pascal Fenske and 10 more. Science, 2017

1,103 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0bd7ff02f596f6e1707a5cbf66cc099212ab38e6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

Citations in the corpus

Metazoan MicroRNAs (2018, background): “…A uthor M anuscript A uthor M anuscript A uthor M anuscript in human and mouse Cdr1as, respectively) (Hansen et al., 2013; Memczak et al., 2013; Piwecka et al., 2017). miRNA REGULATORY MECHANISMS In animals, the recognition and repression of target transcripts can occur through two alternative…”
Circbank: a comprehensive database for circRNA with standard nomenclature (2019, background): “The ceRNA hypothesis proposes that specific RNAs can impair miRNAs activity through sequestration of miRNAs like a sponge, thereby modulating the expression of miRNAs target genes [19 – 21].”
microRNAs in action: biogenesis, function and regulation (2023, neutral): “195,196).”
The Biogenesis, Functions, and Challenges of Circular RNAs. (2018, methodology): “However, it should be noted that conserved miRNA target sites on circRNAs can also be miRNA lodging sites for transport when these sites are only partially complementary to miRNAs (Hansen et al., 2013; Memczak et al., 2013; Piwecka et al., 2017; You et al., 2015).”
Circular RNA-protein interactions: functions, mechanisms, and identification (2020, background): “transmission in the brain, providing a novel insight into the biological functions of circRNAs [9].”