Circular RNAs: Promising Biomarkers for Human Diseases
By Zhongrong Zhang, Tingting Yang, Junjie Xiao. EBioMedicine, 2018
702 citations recorded by the source corpus.
Circular RNA (circRNA) is a group of endogenous noncoding RNA characterized by a covalently closed cyclic structure lacking poly-adenylated tails. Recent studies have suggested that circRNAs play a crucial role in regulating gene expression by acting as a microRNA sponge, RNA binding protein sponge and translational regulator. CircRNAs have become a research hotspot because of their close association with the development of diseases. Some circRNAs are reportedly expressed in a tissue- and development stage-specific manner. Furthermore, due to other features of circRNAs including stability, conservation and high abundance in body fluids, circRNAs are believed to be potential biomarkers for various diseases. In the present review, we provide the current understanding of biogenesis and gene regulatory mechanisms of circRNAs, summarize the recent studies on circRNAs as potential diagnostic and prognostic biomarkers, and highlight the major advantages and limitations of circRNAs as novel biomarkers based on existing knowledge.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/be96924ad04270218a4d2ba4c160cc112a156eb3
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Citations in the corpus
- Circbank: a comprehensive database for circRNA with standard nomenclature (2019, background): “In addition, circRNAs have the potential to be used as biomarkers of diseases due to their stability, specific expression and relation to diseases both in cells and in extra-cellular fluid [12 – 15].”
- The bioinformatics toolbox for circRNA discovery and analysis (2020, background): “CircRNA has been shown to not only be involved in a variety of human diseases [22] including cancers [34], neurodegenerative conditions [35] and cardiovascular illnesses [36] but also participate in plant stress responses [37].”