Self-Renewal and Cancer of the Gut: Two Sides of a Coin

By Freddy Radtke, Hans Clevers. Science, 2005

770 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/1f42fcd0f22d8fa7f9b3b773815af7536dcd6941

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Elaine Fuchs
2. M. Lamkanfi
3. C. Blanpain
4. K. Boyd
5. J. Massagué
6. B. McConnell
7. V. Horsley
8. K. Willert

In Molecular Biology

1. C. Blanpain
2. J. Massagué
3. Pengfei Lu
4. Elaine Fuchs
5. V. Horsley
6. T. Kanneganti
7. Christian A. Luber
8. M. Lamkanfi

In Oncology

1. J. Massagué
2. Elaine Fuchs
3. Matthias Mann
4. C. Blanpain
5. B. McConnell
6. V. Horsley
7. K. Willert
8. K. Jones

Citations in the corpus

• Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. (2009, background): “Interestingly, stimulation of stem cell activity by invasive bacteria is proposed to favor the development of hyperproliferative states found in precancerous lesions (Macdonald and Monteleone 2005; Radtke and Clevers 2005).”
• The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. (2009, background): “differentiate into the cell lineages that occupy the upper third of the crypt: absorptive enterocytes, enteroendocrine cells and mucin-secreting goblet cells [87].”
• Targeting the Hedgehog pathway in cancer (2006, background): “, and the Wnt pathway is activated in the great majority of colon adenocarcinoma cases, often through APC (adenomatous polyposis coli) gene mutation”
• Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. (2006, background): “Activation of NOTCH1 signaling has been recently linked to several malignancies, including glioma (Fan et al., 2004; Purow et al., 2005; Radtke and Clevers, 2005; Weng et al., 2004).”
• The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis (2010, positive): “Epithelial damage induces a localized repair response characterized by increased division of stem cells at the base of crypts to replace damaged enterocytes (Radtke and Clevers, 2005).”
• Wnt signaling: is the party in the nucleus? (2006, background): “To better understand the complex roles of Wnt signaling in development, organogenesis, and cancer, we refer the reader to several excellent recent reviews (Bienz and Hamada 2004; Moon et al. 2004; Nelson and Nusse 2004; Bienz 2005; Gregorieff and Clevers 2005; Kohn and Moon 2005; Radtke and Clevers ”
• SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. (2008, background): “In contrast to heart tissue, in which most cells are quiescent, the intestinal epithelium regenerates within a few days (Radtke and Clevers, 2005).”
• Epithelial stem cells: turning over new leaves. (2007, positive): “The small intestine is a simple epithelium composed of crypt-villus units (Radtke and Clevers, 2005), which function to absorb water and nutrients and to form a functional barrier to protect against ingested pathogens.”
• Cancer metastasis: building a framework. (2006, background): “The Wnt/β-catenin, Hedgehog, and Notch signaling pathways are also implicated in stimulating self renewal in both normal stem cells and malignant cells (Beachy et al., 2004; Radtke and Clevers, 2005).”