Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers.

By George A. Calin, C. Sevignani, C. Dumitru, T. Hyslop, E. Noch, S. Yendamuri, M. Shimizu, S. Rattan, F. Bullrich, M. Negrini and 1 more. Proceedings of the National Academy of Sciences of the United States of America, 2004

4,358 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1dd289afa7bfbde4233bb72d2525572a059ac866

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Citations in the corpus

let-7 regulates self renewal and tumorigenicity of breast cancer cells. (2007, background): “let-7 genes map to sites with frequent chromosomal instability in cancer (Calin et al., 2004), and let-7 is poorly expressed in lung (Takamizawa et al.”
MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. (2005, methodology): “We used an oligonucleotide array prepared in our laboratory (12)”
OncomiRs: the discovery and progress of microRNAs in cancers (2007, background): “The full complement of miRNAs in a genome might be extensively involved in cancers [9].”
Non‐coding RNAs: regulators of disease (2010, background): “MiRNAs are also enriched at fragile sites in the human genome and are associated with oncogenic viral integration sites [142,143].”
Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. (2006, background): “…carcinoma; mlncRNA, mRNA-like noncoding RNA; ND, not defined; MFHs, malignant fibrous histocytomas. aInformation was obtained from previous report (Calin et al., 2004b). bInformation was obtained from previous report (Rodriguez et al., 2004). proportional hazard regression analysis using all of…”
microRNAs join the p53 network — another piece in the tumour-suppression puzzle (2007, background): “and recurrent amplification and deletion of miRNA genes in tumour”
MicroRNAs in cell proliferation, cell death, and tumorigenesis (2006, background): “More than half of miRNAs are located at sites in the human genome that are frequently amplified, deleted, or rearranged in cancer, suggesting that miRNA abnormalities play a broad role in cancer pathogenesis (Calin et al, 2004).”
microRNAs as oncogenes and tumor suppressors. (2007, background): “In humans, let-7 is located at a chromosome region that is usually deleted in human cancers (Calin et al., 2004b).”