Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus.

By M. Peifer, Paul Polakis. Science, 2000

1,341 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1da819609de1b39b6036da3ebbebc792d1533e69

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In Molecular Biology

1. Hans Clevers
2. Elaine Fuchs
3. Linheng Li
4. Thomas Brabletz
5. R. Nusse
6. Matthias Mann
7. A. Gregorieff
8. H. Varmus

Citations in the corpus

• Casein Kinase Iε Modulates the Signaling Specificities of Dishevelled (2004, methodology): “The kinase assays were initiated by the addition of 2 g of GST-Jun(1-109) substrate protein, and 10 Ci of [ -32P]ATP in a volume of 25 l.”
• Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. (2001, background): “More2000; Bienz and Clevers, 2000; Peifer and Polakis, 2000). over, mice lacking LRP-6 exhibited developmental de- fects that are similar to those caused by deficiencies in various Wnt proteins (Pinson et al., 2000).”
• Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway. (2002, background): “Genetic studies in flies, frogs, and mammals positioned the Wnt pathway as a master regulator in animal development, both during embryogenesis and in the mature organism (Wodarz and Nusse 1998; Eastman and Grosschedl 1999; Peifer and Polakis 2000; Huelsken and Birchmeier 2001).”
• Tyrosine residues 654 and 670 in β-catenin are crucial in regulation of Met–β-catenin interactions (2006, background): “Activation of β-catenin due to mutations in β-catenin gene (CTNNB1) or its degradation components such as axin and APC, is observed in many cancers including colorectal, skin, breast and liver [22–24].”
• Phospholipase Cϵ: a novel Ras effector (2001, background): “WNT proteins are secreted proteins that are involved in embryogenesis and cell proliferation (Peifer and Polakis, 2000).”
• Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. (2009, background): “When β-catenin is released in the cytosol, it is phosphorylated in a complex containing the APC protein, axin and GSK3beta kinase, responsible for leading β-catenin to degradation through the ubiquitin–proteasome system [101].”
• Stem cell origin of cancer and differentiation therapy. (2004, background): “Modified from [26,313].”
• The TAK1-NLK Mitogen-Activated Protein Kinase Cascade Functions in the Wnt-5a/Ca2+ Pathway To Antagonize Wnt/β-Catenin Signaling (2003, background): “Given the considerable interest in understanding the roles of the Wnt/ catenin pathway in diverse human cancers (20, 21, 22), our model (Fig.”
• Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin (2013, background): “E-cadherin is a tumor suppressor, which functions through β-catenin (Bryant and Stow, 2004; Peifer and Polakis, 2000).”
• Time zones: a comparative genetics of circadian clocks (2001, background): “Shaggy is best known for its contributions to animal development through the Wnt signal transduction pathwa”
• Getting under the skin of epidermal morphogenesis (2002, background): “The association between defects in adherens junction proteins and human cancers is well established (reviewed in Ref”