The TAK1-NLK Mitogen-Activated Protein Kinase Cascade Functions in the Wnt-5a/Ca2+ Pathway To Antagonize Wnt/β-Catenin Signaling

By Tohru Ishitani, S. Kishida, Junko Hyodo‐Miura, N. Ueno, J. Yasuda, M. Waterman, H. Shibuya, R. Moon, J. Ninomiya-Tsuji, K. Matsumoto. Molecular and Cellular Biology, 2003

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Proximal events in Wnt signal transduction (2009, background): “Different mechanisms have been proposed to explain how non-canonical Wnt signalling might exert this actio”
Tetraspanins: push and pull in suppressing and promoting metastasis (2009, unknown): “, that WNT5A stimulates the Wnt–Ca 2+ signalling pathway (which directly affects actin reorganization, thus modulating cell adhesion and motilit”
Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation (2003, background): “It was reported recently that CaMKII mediates the activity of Wnt-5a in inhibiting canonical Wnt activity without affecting -catenin protein stability in 293 cells (Ishitani et al., 2003), which disagrees with what we have observed in a large number of different cell lines.”
Secreted antagonists of the Wnt signalling pathway (2003, background): “Noncanonical Wnts can even antagonise the canonical pathway (Torres et al., 1996; Kuhl et al., 2001; Ishitani et al., 2003).”