Spatiotemporal Rescue of Memory Dysfunction in Drosophila

By Sean E. McGuire, P. T. Le, Alexander J Osborn, K. Matsumoto, Ronald L. Davis. 2003

1,325 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Immunology, Molecular Biology, Computational Biology & Bioinformatics, Neuroscience

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Citations in the corpus

Genetic dissection of mutual interference between two consecutive learning tasks in Drosophila (2022, methodology): “, 2004) and TARGET (McGuire et al., 2003), were used for transgene expression.”
Dopaminergic neurons write and update memories with cell-type-specific rules (2016, background): “DOI: 10.7554/eLife.16135.001”
Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, background): “…are required specifically in the KCs for memory formation (Livingstone et al., 1984; Zars et al., 2000; Schwaerzel et al., 2003; Kim et al., 2007; McGuire et al., 2003; Gervasi et al., 2010; Qin et al., 2012) and rutabaga was shown to be required for the establishment of the differences in MBON…”
Spacing Effect: SHP2 Phosphatase Regulates Resting Intervals Between Learning Trials in Long-Term Memory Induction (2009, neutral): “Third, we confirmed this observation by expressing the RNAi hairpin constructs in the MB of adult flies by using the spatially and temporally defined TARGET system ( McGuire et al., 2003 ), combining UAS-csw-RNAi with tubulin-GAL80ts;OK107-GAL4.”
Genetic manipulation of genes and cells in the nervous system of the fruit fly (2011, background): “…Triggers endogenous cell death pathway Wing et al., 1998 UAS-hid; TubP-GAL80ts Inducible version of hid Triggers endogenous cell death pathway McGuire et al., 2003 Inhibition of Neuronal Activity UAS-TNT or UAS-TeTxLc Tetanus toxin Blocks chemical synaptic transmission by cleaving…”
The Mushroom Body of Adult Drosophila Characterized by GAL4 Drivers (2009, background): “Therefore, additional temporal control is favorable to circumvent such a ‘‘developmental effect’’ and to restrict the transgene expression to the adult (e.g., GeneSwitch or the GAL80[ts] system) (McGuire et al., 2003; Oster- walder et al., 2001; Roman et al., 2001).”
Drosophila olfactory memory: single genes to complex neural circuits (2007, background): “Selective expression of a rut cDNA in the mushroom bodies, even only in adulthood, restores wild-type memory to rut mutant flie”
Drosophila α/β Mushroom Body Neurons Form a Branch-Specific, Long-Term Cellular Memory Trace after Spaced Olfactory Conditioning (2006, neutral): “…transgene specifically in the MB of adult flies rescues the memory impairment of rutabaga mutants that is observed immediately after olfactory conditioning (McGuire et al., 2003; Mao et al., 2004), indicating that normal rutabaga function in the MBs is required for the expression of early memory.”
Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila (2015, neutral): “…et al., 2008), elav-Gal4C155, elav-Gal4GMR71C07, nrt-Gal4GMR37H03, ase-Gal4 (Zhu et al., 2006), Moody-Gal4 (Schwabe et al., 2005), tubP-GAL80ts[7] (McGuire et al., 2003), UAS-CD8::GFP, UAS-Lsd-2::GFP (kindly provided by Michael Welte), Lsd-2::YFPCPTI001655 (DGRC), UAS-Pros::YFP (Choksi et al.,…”
Forgetting is regulated through Rac activity in Drosophila. (2010, neutral): “Endogenous Rac activation is evoked on different time scales during gradual memory loss in passive decay and during acute memory removal in reversal learning.”
Sequential use of mushroom body neuron subsets during drosophila odor memory processing. (2007, neutral): “Experiments conducted with learning and memory defective mutant flies have led to the prevailing model where MB neurons associate the odor CS with 4 the shock, or sugar US, using potential coincidence detecting molecules like RUT adenylyl cyclase (Zars et al., 2000; McGuire et al., 2003; Mao et al.,”
Atypical Membrane Topology and Heteromeric Function of Drosophila Odorant Receptors In Vivo (2006, methodology): “3 [12], Or22aGal4, Or47b-Gal4 [3], Gr21a-Gal4 [38], oseg2-Gal4 [74], AB1-Gal4 (salivary gland driver) (Bloomington Stock Center, Bloomington, Indiana, United States), tubP-Gal80ts [36], UAS-mCD8:GFP [75], UASGFP:Rab7 [76].”
The Long-Term Memory Trace Formed in the Drosophilaα/β Mushroom Body Neurons is abolished in Long-Term Memory Mutants (2011, neutral): “, 1998) and behavioral experiments that target expression of rescuing transgenes in specific subsets of these neurons (Zars et al., 2000; McGuire et al., 2003; Blum et al., 2009).”