Polycomb silencing mechanisms and the management of genomic programmes

By Y. Schwartz, Vincenzo Pirrotta. Nature reviews genetics, 2007

935 citations recorded by the source corpus.

Subfields: Clinical Psychology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1cc5c3139ca1d88f8c1e7a20890c3e462f2d9c89

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Citations in the corpus

A clustering approach for identification of enriched domains from histone modification ChIP-Seq data (2009, neutral): “…by guest on 28 July 2018 [14:45 26/6/2009 Bioinformatics-btp340.tex] Page: 1953 1952–1958 results from looping action of PRC1 and PRC2 that both anchor at the polycomb response elements (Schwartz and Pirrotta, 2007) with nucleosomes at a distance.”
Cellular senescence and tumor suppressor gene p16 (2011, background): “The polycomb group (PcG) of transcriptional repressor proteins was originally characterized in drosophila as maintenance proteins of pluripotency.(29,30) PRC2 functions”
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. (2008, background): “H3K27me3 is characteristic of PcG target genes and is functional in repression (Schwartz and Pirrotta, 2007).”
Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put (2013, background): “As speculated previously (Schwartz and Pirrotta, 2007; Simon and Kingston, 2009), this could generate chromatin loops and/or rearrangements that juxtapose critical interfaces to influence the transcriptional machinery.”
Regulation of nucleosome dynamics by histone modifications (2013, neutral): “39), and Trithorax-mediated H3K4me3 may thus have an antirepressor function through inhibition of H3K27me3 methylation.”
Long Noncoding RNAs: Past, Present, and Future (2013, background): “These include Ezh2 in PRC2, which is a key H3K27 methyltransferase, and the Pc/Cbx family proteins in PRC1, chromodomain-containing proteins that can bind trimethylated H3K27 (Sparmann and Van Lohuizen 2006; Schwartz and Pirrotta 2007).”
Histone methylation by PRC2 is inhibited by active chromatin marks. (2011, background): “These complexes are conserved in animals and plants and are required to maintain spatially restricted transcription of HOX and other cell fate determination genes (Henderson and Dean, 2004; Pietersen and van Lohuizen, 2008; Schuettengruber et al., 2007; Schwartz and Pirrotta, 2007).”
Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. (2010, positive): “They have since been recognized as global epigenetic transcriptional repressors and key regulators of cell fate (reviewed in Schwartz and Pirrotta, 2007).”
Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. (2008, background): “The repressive role of PcG proteins is counteracted by Trithorax group (TrxG) proteins, which perform H3K4 trimethylation to activate gene expression (Schwartz and Pirrotta 2007).”
Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells. (2007, background): “Polycomb repressive complexes (PRCs), which catalyze H3K27me3 and were initially discovered as regulators of the Homeotic (HOX) genes in Drosophilia (Jurgens, 1985; Lewis, 1978), repress a wide range of targets in mammals (Kirmizis et al., 2004; Schwartz and Pirrotta, 2007; Squazzo et al., 2006).”
Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. (2008, background): “These dynamic Polycomb targets behave very different to Hox genes, which we only observe as actively transcribed or Polycomb repressed, fitting the general model of default Polycomb repression (Ringrose and Paro, 2007; Schwartz and Pirrotta, 2007).”
A model for transmission of the H3K27me3 epigenetic mark (2008, background): “Similar findings have been described for PcG-mediated transcriptional repression in Drosophila”
Genome Regulation by Polycomb and Trithorax: 70 Years and Counting. (2017, positive): “…for their ability to maintain the memory of HOX gene expression patterns throughout development (Cavalli and Paro, 1998; Grimaud et al., 2006b; Margueron and Reinberg, 2011; Poux et al., 2002; Schwartz and Pirrotta, 2007), but how powerful is this memory function, and what are its mechanisms?”