A model for transmission of the H3K27me3 epigenetic mark

By K. Hansen, A. Bracken, Diego Pasini, Nikolaj Dietrich, Simmi S. Gehani, Astrid Monrad, Juri Rappsilber, Mads Lerdrup, K. Helin. Nature Cell Biology, 2008

721 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2722b4448be3df8412f0d40c45e39740ef91df72

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Citations in the corpus

Histone methylation by PRC2 is inhibited by active chromatin marks. (2011, background): “This minimal complex consists of ESC, an E(z) fragment that comprises the ESC binding region at the N terminus, the Su(z) 12 binding domain in the middle (Hansen et al., 2008), and the C-terminal catalytic domain, and the Su(z)12 C terminus harboring the VEFS domain (Figure 5D).”
Mechanisms of Polycomb gene silencing: knowns and unknowns (2009, background): “Recent studies, which track PRC1 and PRC2 behaviours during DNA replicatio”
Epigenetic inheritance during the cell cycle (2009, background): “A similar self-maintaining process has now been proposed for the maintenance of the repressive methylation mark H3K27me3 (H3 trimethylated on residue K27) during replication, in which polycomb repressive complex 2 (PRC2) — which is responsible for setting the H3K27me3 mark — binds to its own methyla”
Charting histone modifications and the functional organization of mammalian genomes (2011, background): “PRC2 association is further stabilized by its own affinity for K27-methylated H3 tail”
A clustering approach for identification of enriched domains from histone modification ChIP-Seq data (2009, neutral): “Availability: http://home.gwu.edu/∼wpeng/Software.htm Contact: wpeng@gwu.edu Supplementary information: Supplementary data are available at Bioinformatics online.”
Rethinking how DNA Methylation Patterns are Maintained (2009, background): “Indeed, there are several examples of chromatin-modifying enzymes that remain associated with their product — for example, EZH2 remains associated with histone H3 trimethylated at lysine 27 — which suggests that this mechanism is common and may be responsible for the inheritance of epigenetic state”
Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa (2010, background): “Furthermore, the catalytic SET domain of Ezh2 is required for long-term repressio”
Chromatin replication and epigenome maintenance (2012, background): “and EZH2 binds H3K27me3 as part of polycomb repressive complex 2 (PRC2”
The Polycomb Complex PRC2 and its Mark in Life (2011, background): “and that the same applies to PRC2 components during mitosi”
The interplay of histone modifications – writers that read (2015, positive): “It has been shown that the binding of PRC2 to the modification it deposits is required for the full establishment of H3K27me3 domains, and such a positive feedback mechanism could also be important for the inheritance of the H3K27me3 mark through cell division [89].”
Structure and function of WD40 domain proteins (2011, background): “It was recently shown that PRC2 maintains histone methylation patterns during DNA replication in part through its ability to bind to H3K27me3 (Hansen et al., 2008).”
Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. (2010, positive): “In addition, the PRC2 protein EZH2 colocalizes with PCNA at foci of ongoing DNA replication, and the PRC2-mediated H3K27me3 modifications positively correlate with late replication of large DNA segments (Birney et al., 2007; Hansen et al., 2008) (Figure 3B).”
Nucleosome-Interacting Proteins Regulated by DNA and Histone Methylation (2010, background): “We identify several known histone methyl-binding proteins in our screen, such as the H3K4me3-interactor CHD1, the H3K9me3-binder UHRF1, and the H3K27me3-interacting polycomb group protein CBX8 (Hansen et al., 2008; Karagianni et al., 2008; Pray-Grant et al., 2005).”