The ToxCast program for prioritizing toxicity testing of environmental chemicals.

By D. Dix, K. Houck, Matt T. Martin, Ann M. Richard, R. Setzer, R. Kavlock. 2007

947 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Environmental Chemistry, Small Animals

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. Simon J. L. Billinge
2. Anubhav Jain
3. Antony J. Williams

In Small Animals

1. Richard S. Judson
2. R. Kavlock
3. Ann M. Richard

Citations in the corpus

• Exploring consumer exposure pathways and patterns of use for chemicals in the environment (2015, background): “Introduction As high-throughput hazard screening approaches such s ToxCast and Tox21 [2,7,9,10,14] continue to evolve, there s a need to develop methods to obtain high-throughput xposure estimates so that chemical hazard screening pproaches and exposure estimates together can allow or the complete d”
• The CompTox Chemistry Dashboard: a community data resource for environmental chemistry (2017, background): “Collectively, these applications have delivered access to in vitro bioassay data [22], chemical and product categories information [23, 24], exposure data [25, 26], experimental and predicted physicochemical property data [27, 28] and, with ACToR [29], thousands of toxicity testing results…”
• Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology (2008, background): “It is estimated, for instance, that there are more than 10,000 environmental chemicals from several Environmental Protection Agency programs that require further testing (Dix et al., 2007).”
• Improving the Human Hazard Characterization of Chemicals: A Tox21 Update (2013, methodology): “EPA obtained concentration– response curves on 309 unique compounds tested across approxi­ mately 550 in vitro and lower organism in vivo assays by various contract and government laboratories (Chandler et al. 2011; Dix et al. 2007; Houck et al. 2009; Judson et al. 2010; Knight et al. 2009; Knudsen ”
• The Next Generation Blueprint of Computational Toxicology at the U.S. Environmental Protection Agency. (2019, background): “Shortly after its formation, NCCT launched the Toxicity Forecaster (ToxCast) project for in vitro high-throughput screening (HTS) of environmental chemicals relevant to the Agency’s mission (Dix et al. , 2007).”
• In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project (2009, methodology): “Environmental Protection Agency (EPA), through its ToxCast program (Dix et al. 2007) and the Tox21 collaboration with the National Toxicology Program and the National Institutes of Health Chemical Genomics Center, is pursuing similar objectives and applying many of the ideas represented in the Natio”
• Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor. (2015, methodology): “These 18 in vitro assays are a subset of a larger collection of assays (821 individual assay endpoints) used in the EPA ToxCast program (Dix et al. , 2007; Judson et al. , 2010; Kavlock et al. , 2012).”
• Recent advances and applications of deep learning methods in materials science (2021, methodology): “Some of the common SMILES datasets are: ZINC [145], Tox21 [146] and PubChem [147].”