Physical approaches to biomaterial design
By S. Mitragotri, Joerg Lahann. Nature Materials, 2009
1,335 citations recorded by the source corpus.
The development of biomaterials for drug delivery, tissue engineering and medical diagnostics has traditionally been based on new chemistries. However, there is growing recognition that the physical as well as the chemical properties of materials can regulate biological responses. Here, we review this transition with regard to selected physical properties including size, shape, mechanical properties, surface texture and compartmentalization. In each case, we present examples demonstrating the significance of these properties in biology. We also discuss synthesis methods and biological applications for designer biomaterials, which offer unique physical properties.
Subfields: Biomaterials, Biomedical Engineering
View Paper: https://www.semanticscholar.org/paper/e3ca254a56c0cbedbe49c120e9a610ede88e5c82
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In Biomaterials
- S. Mitragotri
- Harold G. Craighead
- Christine P. Tan
- Joseph M. DeSimone
- Anna Salvati
- Christoffer Åberg
- Z. Sheikh
- H. Yang
In Biomedical Engineering
- Christine P. Tan
- Ulrich S. Schwarz
- Shmuel Safran
- Harold G. Craighead
- S. Plimpton
- D. Di Carlo
- Z. Sheikh
- D. Irvine
Citations in the corpus
- Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface. (2013, positive): “While it is clear that nanoparticle size and shape are key factors for uptake 15-17 , current targeting strategies also involve conjugation of biofunctional moieties to nanoparticles in an effort to determine the biological outcomes 1,2,9,12,18-20 .”
- Macrophages, Foreign Body Giant Cells and Their Response to Implantable Biomaterials (2015, background): “High surface-to-volume implants such as porous materials show higher ratios of macrophages and foreign body giant cells than do the smooth-surface implants [155].”
- Microwave-assisted polymer synthesis (MAPS) as a tool in biomaterials science: How new and how powerful (2011, background): “The design and synthesis of on-demand biomaterials has become an emerging area of (bio)pharmaceutical research [20].”