Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

By N. Maeda, I. Shimomura, K. Kishida, H. Nishizawa, M. Matsuda, H. Nagaretani, N. Furuyama, H. Kondo, Masahiko Takahashi, Y. Arita and 10 more. Nature Medicine, 2002

2,187 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/2cd470528312751d1abb0908fad029767970f22d

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In Epidemiology

1. Haiming Cao
2. P. Scherer
3. Herbert Tilg
4. B. Spiegelman
5. H. Fang
6. R. L. Judd
7. Mitchell A. Lazar
8. A. Moschen

In Molecular Biology

1. B. Spiegelman
2. E. Rosen
3. Herbert Tilg
4. Haiming Cao
5. Mitchell A. Lazar
6. A. Hevener
7. R. Barnard
8. Christian K. Roberts

In Physiology

1. Haiming Cao
2. P. Scherer
3. Mitchell A. Lazar
4. B. Spiegelman
5. E. Rosen
6. Herbert Tilg
7. F. B. Hu
8. A. Moschen

Citations in the corpus

• APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function (2006, background): “In mice, targeted deletion of the adiponectin gene leads to insulin resistanc”
• Adipokines Mediate Inflammation and Insulin Resistance (2013, background): “Exogenous administration of adiponectin or overexpression in transgenic mice results in improved insulin sensitivity whereas adiponectin deficient mice develop HFD-induced inflammation and insulin resistance (Maeda et al., 2002; Kim et al., 2007b).”
• Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study. (2003, background): “Obesity also decreases adipocyte expression of adiponectin, which has anti-inflammatory and insulin-sensitizing effects (26).”
• Adiponectin: action, regulation and association to insulin sensitivity (2005, background): “It is suggested that adiponectin plays an important role in lipid metabolism, however, whether FFA regulate adiponectin levels remains unclear.”
• Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms (2005, neutral): “Adiponectin-knockout (APN-KO) mice have diet-induced insulin resistanc”
• Obesity-induced inflammatory changes in adipose tissue. (2003, background): “For example, exploring the contributions of TNF-α, adiponectin, JNK, and inhibitor of NF-κB kinase β (IKKβ) (2, 12, 13, 15) to adipose tissue inflammation in mice with null mutations in these genes might provide insights into the aspects of the inflammatory response that are relevant to insulin acti”