CBP histone acetyltransferase activity is a critical component of memory consolidation.

By E. Korzus, Michael G. Rosenfeld, M. Mayford. Neuron, 2004

845 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1b4041a1b898dc54a6cfef364ed36e30c4bb5d09

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In Molecular Biology

1. E. Nestler
2. F. Lubin
3. T. Roth
4. J. Sweatt
5. W. Renthal
6. Arvind Kumar
7. Nadia M. Tsankova
8. C. Alberini

Citations in the corpus

• EPIGENETIC REGULATION OF BDNF GENE TRANSCRIPTION IN THE CONSOLIDATION OF FEAR MEMORY (2008, background): “…remodeling can control gene transcription in the nervous system and modulates long-term memory formation (Guan et al., 2002; Alarcón et al., 2004; Korzus et al., 2004; Levenson et al., 2004, 2006; Kumar et al., 2005; Chwang et al., 2006; Bredy et al., 2007; Fischer et al., 2007; Lubin and…”
• Epigenetic mechanisms in memory formation (2005, background): “The first study linked the dominant-negative allele of CBP to an inducible promoter (CBP I-DN +/−”
• How can memories last for days, years, or a lifetime? Proposed mechanisms for maintaining synaptic potentiation and memory (2019, background): “Overall, the above discussion suggests it is likely that several positive feedback loops act in concert, with each one a necessary component, for long-term maintenance of at least some forms of LTP and LTM.”
• Plastic Synaptic Networks of the Amygdala for the Acquisition, Expression, and Extinction of Conditioned Fear (2010, positive): “CREB activation is also linked to histone acetylation through the CREB-binding protein CBP (214), which is itself required for the acquisition of conditioned fear (342).”
• Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation (2007, background): “, 2004) or transgenic mice expressing a transgene that contained a point mutation in the CBP HAT domain (Korzus et al., 2004).”
• Covalent modification of DNA regulates memory formation. (2007, positive): “Recent evidence indicates that regulation of chromatin structure serves as an important control mechanism in memory-associated transcriptional regulation (Swank and Sweatt, 2001; Guan et al., 2002; Huang et al., 2002; Levenson et al., 2004a, 2006; Korzus et al., 2004; Alarcon et al., 2004; Wood et a”
• Epigenetic regulation in psychiatric disorders (2007, background): “Mice deficient in CBP exhibit memory deficits in several hippocampus-dependent memory tests, including spatial mazes, contextual fear conditioning and novel object recognition, and administration of an HDAC inhibitor can restore normal long-term memory formation in the mutant”