Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor.

By F. Stermitz, P. Lorenz, J. Tawara, Lauren A. Zenewicz, K. Lewis. Proceedings of the National Academy of Sciences of the United States of America, 2000

759 citations recorded by the source corpus.

Subfields: Molecular Medicine, Pharmacology

View Paper: https://www.semanticscholar.org/paper/1b1269fb06133b27191b1400796ddf9f4c4d5f96

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Medicine

1. L. Piddock
2. Kim Lewis
3. J. Ghigo
4. D. Lebeaux
5. C. Beloin
6. H. Nikaido
7. Xian-Zhi Li
8. Gerard D. Wright

In Pharmacology

1. P. R. Henika
2. M. Friedman
3. Kim Lewis
4. R. Mandrell
5. Gerard D. Wright
6. H. Nikaido

Citations in the corpus

• Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine (2008, background): “1), which have no antibacterial activity but have an inhibitory property against the multi-drug resistant (MDR) efflux pumps found so far in S. aureus (Stermitz et al., 2001, 2000).”
• Natural products and drug discovery (2009, background): “Several years ago, Lewis and coworkers showed that the high anti microbial potential of Berberis spp. (Pepperidge bush) is caused not only by antimicrobial agents such as berberine, but also by multidrug-resistance (MDR) inhibitors such as 5’-methoxyhydnocarpin (Stermitz et al, 2000).”
• Multidrug tolerance of biofilms and persister cells. (2008, background): “Plants, however, in addition to berberine, also make methoxyhydnocarpin, an MDR inhibitor that disables the resistance mechanism of Gram-positive pathogens and acts in synergy with the antimicrobial ( Stermitz et al. 2000a ).”
• Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria (2006, background): “(211) later showed that plant extracts contain an inhibitor of NorA (5 -MHC) that potentiates the activity of berberine.”
• Bactericidal activities of plant essential oils and some of their isolated constituents against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes, and Salmonella enterica. (2002, background): “The increasing antibiotic resistance of some pathogens that are associated with foodborne illness is another concern (30, 33, 38, 39).”
• Medicinal plants and antimicrobial activity. (2005, background): “…known activity of the plant and likewise follow a guid f ′-methoxyhydnocarpin, a compound isolated from ch oogra oil, on the activity of berberine (Stermitz et al., 2000). hile 5′-methoxyhydnocarpin exhibited no antimicrob ctivity on its own, it greatly enhanced the action of ber ne…”