Multidrug tolerance of biofilms and persister cells.

By Kim Lewis. Current Topics in Microbiology and Immunology, 2008

820 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/042f866afc38d093aafae7ab1c8e068cab25d76b

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Citations in the corpus

Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options. (2013, background): “, 2012), and these have gathered some attention recently in the context of fungal biofilms (Lewis, 2008; Bink et al., 2011).”
Pseudomonas Aeruginosa: Resistance to the Max (2011, background): “One explanation for biofilms being generally refractory to antimicrobial chemotherapy is the presence, in biofilms, of a highly resistant sub-population of cells called persisters (Lewis, 2008).”
Healthcare-associated infections, medical devices and biofilms: risk, tolerance and control. (2015, neutral): “(Spoering & Lewis, 2001; Hall-Stoodley et al., 2004; Lewis, 2008, 2010; Percival et al., 2011).”
Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence (2017, background): “They are abundant in P. aeruginosa biofilms which is the hallmark of longterm infections particularly in CF patients (Lewis, 2008; Mulcahy et al., 2010).”
Bacterial biofilm development as a multicellular adaptation: antibiotic resistance and new therapeutic strategies. (2013, background): “Another phenomenon that contributes significantly to antibiotic resistance in biofilms is persistence, a property of the so-called persister cells, which are more numerous in biofilms than in planktonic populations [32,33].”
Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics (2014, methodology): “The presence of an isogenic subpopulation of tolerant bacteria, called “persister cells” or “persisters,” is now considered to explain most of the biofilm recalcitrance toward antibiotics (31).”
Prevalence and Therapies of Antibiotic-Resistance in Staphylococcus aureus (2020, background): “Antibiotics can cause fatal damage to bacteria, but persister cells can resist this killing by reducing cell growth and metabolism, and even by becoming dormant (Lewis, 2008).”
Bacterial Persister Cell Formation and Dormancy (2013, background): “Persister cells, those cells tolerant to antibiotics, usually comprise about 1% in the stationary state and in biofilms (1, 2).”
Bacterial Biofilms: Development, Dispersal, and Therapeutic Strategies in the Dawn of the Postantibiotic Era (2013, background): “Studies have shown the presence of metabolically inactive nondividing persister cells within biofilms, which are tolerant to a number of antibiotics despite the fact that they are genetically identical to the rest of the bacterial population (Lewis 2005, 2008).”