Endothelial-pericyte interactions in angiogenesis

By Holger Gerhardt, C. Betsholtz. Cell and Tissue Research, 2003

1,089 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1aaffc5017d8b6d37d60f459a58090d7f10b6e7d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Berislav Zlokovic
2. G. Bergers
3. Richard J. Gilbertson
4. Helmut Kettenmann
5. D. Hanahan

In Molecular Biology

1. D. Hanahan
2. K. Alitalo
3. Berislav Zlokovic
4. Rakesh K. Jain
5. G. Bergers
6. R. Bell
7. D. McDonald
8. Zena Werb

Citations in the corpus

• Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis (2004, background): “Vascular mural cells regulate endothelial cell sprouting, proliferation and differentiation during the vascular maturation phase, as well as blood capillary shape and diameter (reviewed in refs”
• Direct 3D bioprinting of perfusable vascular constructs using a blend bioink (2016, neutral): “CD31 is an endothelial-specific adhesion protein expressed on the membranes of endothelial cells and comprises a major chunk of the intercellular junction complexes [64,65], while a-SMA is the actin isoform that predominates within vascular SMCs and plays an important role in angiogenesis [66,67].”
• Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches (2019, background): “In addition to nonperivascular Lyve1MHCII IMs, which most likely associate with capillaries (34), there was a major population of Lyve1 macrophages closely associated with CD31 blood vessels in these organs (Fig.”
• Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. (2004, result): “These observations indicate that disruption of endothelial cell function by antagonism of VEGF signaling leads to altered pericyte function, consistent with the interdependency of endothelial cells and pericytes in angiogenesis.(52) They also suggest that functional abnormalities rather than absence”
• Modes of resistance to anti-angiogenic therapy (2008, background): “A growing body of evidence indicates that pericytes, the periendothelial support cells of the microvasculatur”
• Cellular abnormalities of blood vessels as targets in cancer. (2005, background): “Pericytes Pericytes are key cells in vascular development, stabilization, maturation and remodeling [23,24].”
• Central nervous system pericytes in health and disease (2011, background): “Whether endothelial tube formation precedes and guides pericyte migration or, alternatively, pericyte migration precedes and guides tube formation remains debatabl”
• Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. (2011, background): “This was connected to reduced vascular expression of N-cadherin, a cell adhesion molecule believed to mediate heterotypic cell contacts between endothelial cells and pericytes (Gerhardt and Betsholtz, 2003; Gerhardt et al., 2000).”
• The role of pericytes in blood-vessel formation and maintenance. (2005, background): “Pericytes induce endothelial differentiation and growth arrest (Gerhardt and Betsholtz, 2003; Hirschi Fig.”
• The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction (2009, background): “During development, the proteoglycan, NG2, provides a further excellent surface marker that allows visualization of the entire extension of pericytes on the endothelial plexus [36].”
• HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. (2008, background): “The most prominent factors identified thus far include VEGF, angiopoietin-1, PlGF and PDGF-B, which mobilize EPCs and PPCs, respectively (Hattori et al., 2001; Li et al., 2006; Rabbany et al., 2003; Gerhardt and Betsholtz, 2003 ), and SDF1a, which can facilitate CXCR4+ BMDC retention within tumors ”
• The brain tumor microenvironment (2011, background): “Endothelial cells recruit PDGF-expressing pericytes that function to stabilize the outer lining of newly developing vasculature for angiogenesis (Gerhardt and Betsholtz, 2003).”