HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion.

By R. Du, K. Lu, C. Petritsch, Patty Liu, R. Ganss, E. Passegué, Hanqiu Song, S. Vandenberg, Richard J. Johnson, Zena Werb and 1 more. Cancer Cell, 2008

1,165 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1e71c31ff617de3d7816efb4e681eaaf962cf47f

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Citations in the corpus

HIF Transcription Factors, Inflammation, and Immunity (2014, background): “For instance, CCL5 and C-X-C motif chemokine 12 (CXCL12, also known as SDF1a) production by hypoxic tumor cells is driven by HIF-1a (Du et al., 2008; Lin et al., 2012), and chemokine receptor C-X-C motif chemokine receptor (CXCR4) expression by myeloid and tumor cells is regulated by the VHL-HIF…”
The metastatic niche: adapting the foreign soil (2009, background): “Tissue hypoxia has been associated with several aspects of malignant progression including metastasi”
The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications (2020, background): “Macrophages could regulate angiogenesis in the TME by secreting different molecules to mobilize or neutralize vascular endothelial growth factor to exert proangiogenic or antiangiogenic functions.(170) Similarly, macrophages are also crucial orchestrators of tumor-associated fibrosis through differe”
Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells. (2011, background): “…tumor vasculature indeed enhances tumor hypoxia, which in turn upregulates the expression of several myeloid cell chemoattractants (e.g., stromal cell-derived factor-1, SDF1) that rouse the influx of myeloid cells to treated tumors (Bergers and Hanahan, 2008; Chan et al., 2009; Du et al., 2008).”
Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. (2008, background): “Accumulating data have shown that MDSCs infiltrate into tumors and promote tumor angiogenesis by producing high levels of matrix metalloproteinase-9 (MMP9) and by directly incorporating into tumor endothelium (Ahn and Brown, 2008; Du et al., 2008).”