Cancer exosomes trigger fibroblast to myofibroblast differentiation.

By J. Webber, R. Steadman, M. Mason, Z. Tabi, Aled Clayton. Cancer Research, 2010

771 citations recorded by the source corpus.

Subfields: Molecular Biology, Surgery, Urology

View Paper: https://www.semanticscholar.org/paper/1a927d321101e13ec183d980e984d2bed8250783

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Citations in the corpus

Fibroblast heterogeneity in the cancer wound (2014, background): “…exosomes can transfer protein, RNA, and microRNA (miR) from one cell to another, and cancer-derived exosomes have been shown to contribute to the recruitment and activation of fibroblasts and MSCs within tumors (Webber et al., 2010; Cho et al., 2012; Gu et al., 2012; Kahlert and Kalluri, 2013).”
Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance (2019, background): “cancers, thus exosomes playing a crucial role in ECM remodeling and TME reprogramming [63, 64].”
Hypoxic enhancement of exosome release by breast cancer cells (2012, background): “Exosome-mediated signalling promotes tumour progression through communication between the tumour and surrounding stromal tissue [6], activation of proliferative and angiogenic pathways [5,7], by bestowing immune suppression [8,9], and initiation of pre-metastatic sites [10].”
The biology, function, and biomedical applications of exosomes (2020, positive): “For example, TGFb (transforming growth factor-b) expressed on the surface of cancer cell–derived exosomes induces fibroblast activation by gain of aSMA (a-smooth muscle actin) and FGF2 (fibroblast growth factor 2) expression (153).”
Tumor-derived exosomes and their role in cancer progression (2016, background): “Cancer-derived exosomes have been shown to induce such changes in fibroblasts through the TGFβ/Smad pathway [57, 77].”
Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function (2015, background): “…Webber et al. incubated exosomes derived from a mesothelioma cell line, a prostate cancer cell line, a bladder cancer cell line, a colorectal cancer cell line, and a breast cancer cell line with primary ﬁbroblasts in vitro , and found that ﬁbroblasts could be transformed into myoﬁbroblasts [48].”
Biological properties of extracellular vesicles and their physiological functions (2015, background): “While the nature of the cytokine association with the various EVs in general is poorly understood, the role of heparan sulphate proteoglycans in tethering TGF-beta to the vesicle membrane, and its functional handover to recipient cells, has been reported (156,157).”
Extracellular vesicles in cancer: cell-to-cell mediators of metastasis (2016, background): “Tumor-derived exosomes containing TGF-β convert fibroblasts into myofibroblasts, contributing to vascularization, tumor growth and local invasion (De Wever et al., 2008; Webber et al., 2010).”
Exosome-Based Cell-Cell Communication in the Tumor Microenvironment (2018, background): “EMT is also modulated by CAF-derived exosomes containing miRs-21, −278e, and−143, influencing breast cancer cell phenotype and aggressiveness (Donnarumma et al., 2017).”
Exosomes in cancer: small particle, big player (2015, background): “suggest that prostate cancer cells could trigger differentiation of fibroblasts into myofibroblasts through exosomal TGF-β [66].”
Exosomes and their roles in immune regulation and cancer. (2015, background): “[60] Webber J, Steadman R, Mason MD, Tabi Z, Clayton A.”
Biodistribution and Delivery Efficiency of Unmodified Tumor-Derived Exosomes (2014, background): “The growing evidence of exosomes' innate ability to deliver naturally incorporated cargo to recipient cells has excited the drug delivery field [1–11].”