Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

By Ladan Mashouri, Hassan Yousefi, A. Aref, A. Ahadi, F. Molaei, S. Alahari. Molecular Cancer, 2019

1,297 citations recorded by the source corpus.

Tumor-derived exosomes (TDEs) participate in formation and progression of different cancer processes, including tumor microenvironment (TME) remodeling, angiogenesis, invasion, metastasis and drug-resistance. Exosomes initiate or suppress various signaling pathways in the recipient cells via transmitting heterogeneous cargoes. In this review we discuss exosome biogenesis, exosome mediated metastasis and chemoresistance. Furthermore, tumor derived exosomes role in tumor microenvironment remodeling, and angiogenesis is reviewed. Also, exosome induction of epithelial mesenchymal transition (EMT) is highlighted. More importantly, we discuss extensively how exosomes regulate drug resistance in several cancers. Thus, understanding exosome biogenesis, their contents and the molecular mechanisms and signaling pathways that are responsible for metastasis and drug-resistance mediated by TDEs may help to devise novel therapeutic approaches for cancer progression particularly to overcome therapy-resistance and preventing metastasis as major factors of cancer mortality.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/55229c6b649b75f257f1f5d48eb5456cfd5930dc

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Citations in the corpus

• The exosome journey: from biogenesis to uptake and intracellular signalling (2021, background): “ESCRT machinery plays a prominent role in this process, with SNARE proteins and their effectors such as RAB GTPases playing important role in their secretion alongside [5, 31].”