TRBP, a regulator of cellular PKR and HIV‐1 virus expression, interacts with Dicer and functions in RNA silencing

By A. Haase, Lukasz Jaskiewicz, Haidi zhang, S. Lainé, R. Sack, A. Gatignol, W. Filipowicz. EMBO Reports, 2005

734 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/1a6f02f7e5b8cd72dfc572b3301589c3bd438118

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Citations in the corpus

Illuminating the silence: understanding the structure and function of small RNAs (2007, background): “The assembly of these components into miRISC has been implicated in miRNA function”
Specialization and evolution of endogenous small RNA pathways (2007, neutral): “gov/sites/entrez?db=gene&amp=&amp=&amp=&cmd=Retrieve&dopt=full_report&list_uids=6895">TRBP ) in mammal”
Posttranscriptional regulation of microRNA biogenesis in animals. (2010, background): “In the cytoplasm, the pre-miRNA gets further ‘‘diced’’ into a 22 nt long miRNA duplex by Dicer, another RNase III enzyme, in collaboration with the dsRBD Molecular Cell 38, May 14, 2010 ª2010 Elsevier Inc. 323 proteins TRBP/PACT (Chendrimada et al., 2005; Haase et al., 2005; Lee et al., 2006).”
Small RNA sorting: matchmaking for Argonautes (2010, background): “For this purpose, the sole mammalian Dicer partners with the dsRBD protein TAR RNA-binding protein 2 (TARBP2, also known as TRBP”
Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action (2006, background): “Interestingly, TRBP is described as a dsRBD protein partner of human Dicer, which is required for optimal RNA silencing mediated by siRNA and endogenous micro RNA (137).”
MicroRNA regulation by RNA-binding proteins and its implications for cancer (2011, background): “The cofactor TARBP2 uses two dsRNA-binding domains (dsRBDs) to interact with the pre-miRNA, stimulating Dicer-mediated cleavage, and a third dsRBD to increase the stability of the Dicer–RNA comple”
MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions (2016, background): “Mature agotrons are similar to pre-miRNAs (80–100 nt), and their biogenesis is independent of both Drosha and Dicer although they are ultimately associated and stabilized by Argonaute (AGO) proteins [14]. pre-miRNAs are translocated to the cytoplasm in a process mediated by Exportin5 (XPO5), a membe”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, methodology): “Humans have a single isoform of Dicer that functions in both the siRNA and miRNA pathways [108, 109].”
Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis. (2025, positive): “AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP (Chendrimada et al., 2005; Gregory et al., 2005; Haase et al., 2005; MacRae et al., 2008; Maniataki and Mourelatos, 2005; Melo et al., 2009).”
MicroRNA function: multiple mechanisms for a tiny RNA? (2005, background): “Thus, it is clear that the effect on mRNA level is unlikely to be mediated by the RISC cleavage pathway, as for cleavage to occur, an A-form helix must be formed between the miRNA and the target mRNA (Chiu and Rana 2003; Haley and Zamore 2004).”