Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action

By María García, J. Gil, I. Ventoso, Susana Guerra, E. Domingo, C. Rivas, M. Esteban. Microbiology and Molecular Biology Reviews, 2006

832 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0872f966974442c9ae40baa81a09043a32a3c0c6

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In Immunology

1. R. Randall
2. S. Goodbourn

In Molecular Biology

1. M. A. Saad
2. P. Prada
3. R. Randall
4. A. C. Santos
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6. Wenshuai Wang
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Citations in the corpus

• Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol (2012, background): “Interferon-induced transmembrane protein 3 (IFITM3) proteins block viral entry, and ISG20, a 30-50 exonuclease, degrades single-stranded viral RNA; PKR inhibits viral translation through suppression of eIF2a elongation factors and tetherin prevents release of virions from the cell (Garcı́a et al., 2”
• Dynamic light scattering: a practical guide and applications in biomedical sciences (2016, background): “PKR is a major player of innate immunity providing support against viral infection by recognising viral doublestranded RNA, and ultimately influences a number of cellular activities (Garcia et al. 2006).”
• Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. (2008, background): “dsRNA-dependent protein kinase R (PKR) (Garcia et al., 2006), 2959-oligoadenylate synthetase (OAS) (Clemens, 2005; Silverman, 2007) and Mx (Martens & Howard, 2006; Haller et al.”
• Inhibition of PKR by Viruses (2021, background): “Previous reviews provide a broad view on the biology of PKR, its activation process, its many activities (Garcia et  al., 2006, 2007), and its antiviral functions and viral countermeasures (Dauber and Wolff, 2009; Walsh and Mohr, 2011; Dabo and Meurs, 2012; Dzananovic et  al., 2018).”
• Linking Gut Microbiota and Inflammation to Obesity and Insulin Resistance. (2016, background): “Viral infections also activate pattern recognition receptors (PRRs) and the double-stranded RNAactivated protein kinase receptor (PKR), which trigger an immune response (43, 94).”
• The multifunctional NS1 protein of influenza A viruses. (2008, background): “Both OAS/RNase L and PKR are key regulators of viral transcription/translation processes, but play additional roles in other innate defences such as IFN-b induction and the host apoptotic response (Garcia et al., 2006; Silverman, 2007).”
• The integrated stress response (2016, neutral): “Interestingly, other stresses such as oxidative and ER stress [44,45], growth factor deprivation, cytokine or bacterial infection [46,47], ribotoxic stress [48], stress granules [49], and heparin [50] have also been shown to stimulate PKR, but in a dsRNA-independent manner.”