Neurobiology of Relapse to Heroin and Cocaine Seeking: A Review

By U. Shalev, Jeffrey W Grimm, Y. Shaham. Pharmacological Reviews, 2002

900 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/1a4c9d23599eeb65aabd93af48389c072dbe1727

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Peter W. Kalivas
2. G. Koob
3. Nora D. Volkow
4. J. Steketee
5. Y. Shaham
6. M. Le Moal
7. J. Stewart
8. Kent C. Berridge

In Cognitive Neuroscience

1. Peter W. Kalivas
2. G. Koob
3. Nora D. Volkow
4. Y. Shaham
5. J. Steketee
6. U. Shalev
7. K. McFarland
8. M. Le Moal

Citations in the corpus

• The reinstatement model of drug relapse: history, methodology and major findings (2003, background): “In heroin-trained rats, ventricular infusions of leptin, a hormone involved in energy balance and body weight regulation (Friedman and Halaas 1998), attenuate reinstatement induced by food deprivation, but not by heroin priming or footshock (Shalev et al. 2002c).”
• Addiction and the brain antireward system. (2008, background): “Thus, memory mechanisms may contribute to the allostatic state by associative mechanisms linked to both the reward and antireward systems. tended amygdala (CeA and BNST) (Shaham et al. 2003, Shalev et al. 2002).”
• Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse (2003, methodology): “The reinstatement of drug-seeking behavior in rats is commonly used to model relapse in human addict”
• The Cystine/Glutamate Antiporter System xc − in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities (2013, positive): “The importance of down-regulated system xc - in the reinstatement of cocaine-seeking behavior, an animal model of relapse (246), was revealed by finding that NAC-mediated restoration of system xc - activity prevents reinstated cocaine seeking (8, 112).”
• The neural basis of addiction: a pathology of motivation and choice. (2005, background): “The behavior is extinguished, making it possible to reinstate drug seeking by exposing the animals to stimuli similar to those that elicit craving in human addicts, such as a cue previously associated with drug delivery, a mild stressor, or a single dose of the drug (18).”
• Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure (2006, methodology): “In reinstatement studies, nicotine, opiates, or psychostimulants are administered by acute injections via the intravenous, intraperitoneal, or subcutaneous routes (Shalev et al. 2002), paralleling the rapiddelivery modes of administration that are associated with drug abuse (Jaffe 1990; Johanson and”
• Drug Wanting: Behavioral Sensitization and Relapse to Drug-Seeking Behavior (2011, background): “Reinstatement can be influenced by a number of factors, including food training before drug training, use of noncontingent drug primes during training, amount of drug intake during training, and the length of withdrawal before reinstatement testing (Shalev et al., 2002).”
• Brain circuitry and the reinstatement of cocaine-seeking behavior (2003, background): “Consistent with the involvement of the BNST and central amygdala, the noradrenergic neurons in the lateral pontine tegmentum project to both of these nuclei (Aston-Jones et al. 1999), and the projection to the BNST has been shown to be involved in stress-primed reinstatement (Shalev et al. 2002).”
• Neurobiology of the incubation of drug craving (2011, positive): “Many studies using animal models indicate that the mesocorticolimbic dopamine system and the nigrostriatal dopamine system both contribute to cue-induced cocaine seeking [14, 50, 51] and other behavioral effects of cocaine, including cocaine reward [52, 53].”