Neurobiology of the incubation of drug craving
By C. Pickens, M. Airavaara, F. Theberge, Sanya Fanous, B. Hope, Y. Shaham. Trends in Neurosciences, 2011
627 citations recorded by the source corpus.
It was suggested in 1986 that cue-induced drug craving in cocaine addicts progressively increases over the first several weeks of abstinence and remains high for extended periods. During the last decade, investigators have identified an analogous incubation phenomenon in rodents, in which time-dependent increases in cue-induced drug seeking are observed after withdrawal from intravenous cocaine self-administration. Such an incubation of drug craving is not specific to cocaine, as similar findings have been observed after self-administration of heroin, nicotine, methamphetamine, and alcohol in rats. In this review, we discuss recent results that have identified important brain regions involved in the incubation of drug craving, as well as evidence for the underlying cellular mechanisms. Understanding the neurobiology of the incubation of drug craving in rodents is likely to have significant implications for furthering our understanding of brain mechanisms and circuits that underlie drug craving in human addicts.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/bff7f9956db6877597c79d6f73f7b1faf2bc10fb
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In Cellular and Molecular Neuroscience
In Molecular Biology
Citations in the corpus
- DSM-5 Criteria for Substance Use Disorders: Recommendations and Rationale (2013, background): “Craving is an exception because it can persist long into remission (109, 110).”
- Transcriptional and Epigenetic Mechanisms of Addiction (2011, background): “Instead, the field needs to make greater use of drug self-administration and relapse assays, which are considered the best available animal models of addictio”