Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders.

By R. Sapolsky. Archives of General Psychiatry, 2000

2,040 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Endocrinology, Diabetes and Metabolism

View Paper: https://www.semanticscholar.org/paper/19b7409412760d1f3d2788a4b71801c707d5b463

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Citations in the corpus

Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. (2003, background): “Stress, which can precipitate and exacerbate depression, causes neuronal atrophy and death, especially in the hippocampus (Magarinos and McEwen 1995a, 1995b; McEwen 2000; Sapolsky 2000).”
Associations between parents' marital functioning, maternal parenting quality, maternal emotion and child cortisol levels (2007, background): “As such, frequent or chronic elevation of cortisol levels are thought to play a role in the development of emotional and physical disorder in humans (Sapolsky, 2000).”
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms (2008, background): “Sustained levels of stress or glucocorticoids also damage the hippocampus at the level of morphological neuroplasticity (reviewed in Sapolsky, 2000) (Figure 2).”
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “Thus, recurrent episodes of MDD promote increased levels of glucocorticoids and stress-induced morphological damage in the hippocampus, which could lead to HPA overactivation and sustained hippocampal atrophy (McEwen, 1999; Sapolsky, 2000).”
A Research Agenda For DSM-V (2002, background): “In animal studies, the presence of chronically elevated glucocorticoids has been implicated in neuronal atrophy (Sapolsky 2000), and indeed, recent morphometric studies (Ongur et al.”
A meta-analysis of structural brain abnormalities in PTSD. (2006, background): “Because of its critical role in learning and memory as well as stress regulation, alterations in the hippocampus have been proposed as contributing to the etiology of PTSD (Bremner, 2001; Sapolsky, 2000).”
Depression: perspectives from affective neuroscience. (2002, background): “…2000; Mervaala et al. 2000; but see Vakili et al. 2000, Ashtari et al. 1999), bipolar disorder (Noga et al. 2001), posttraumatic stress disorder (Bremner et al. 1995, 1997b, Stein et al. 1997), and borderline personality disorder (Driessen et al. 2000) (for review, see Sapolsky 2000, Sheline 2000).”
THE PILOCARPINE MODEL OF TEMPORAL LOBE EPILEPSY (2008, background): “Glucocorticoids are known to enhance the lesion caused by several agents in the hippocampus (Sapolsky, 2000).”