Intracellular Bacterial Biofilm-Like Pods in Urinary Tract Infections

By Gregory G. Anderson, Joseph J. Palermo, Joel D. Schilling, Robyn Roth, J. Heuser, Scott J. Hultgren. Science, 2003

1,035 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/1954a6e8cc8af0473d8b3ec467e314bc692be1ab

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In Epidemiology

S. Hultgren

In Molecular Biology

Citations in the corpus

Why chronic wounds will not heal: a novel hypothesis (2008, neutral): “With regard to antibiotic therapy, there is a lack of evidence concerning optimal regimes or clinical hallmarks for efficient treatment and additionally, biofilm infections are characterized by resistance to the host defenses.(2,19,20) If this is also true for infected chronic wounds, it explains wh”
Specialized Persister Cells and the Mechanism of Multidrug Tolerance in Escherichia coli (2004, neutral): “This method produces densely packed cells that closely resemble a clinically relevant E. coli bladder cell biofilm ( 2 ).”
Bacterial adhesins in host-microbe interactions. (2009, neutral): “Each internalized UPEC bacterium can rapidly replicate to as many as 10 bacteria per cell, resulting in the maturation of intracellular bacterial communities (IBCs), a niche with biofilm-like properties protected from innate defenses and antibiotics (Anderson et al., 2003; Justice et al., 2006).”
Bacterial adhesion and entry into host cells. (2006, neutral): “Cdc42 and RhoA are also required for the FimH-dependent cell invasion process by UPEC (Martinez and Hultgren, 2002).”
Bacterial Biofilm and its Role in the Pathogenesis of Disease (2020, neutral): “IBC were first described in a mouse model using an immunosuppressed mouse strain and UPEC [211], the primary UTI-pathogen accounting for 70–95% of cases.”
Evolving concepts in biofilm infections (2009, neutral): “Recently another UTI pathogen, Klebsiella pneumoniae, was shown to develop intracellular biofilms linked to the expression of type 1 pili (Rosen et al., 2008) and intracellular UPEC exhibiting the same phenotype in epithelial cells present in human UTI infections has been described (Rosen et al., 20”
Molecular mechanisms of Escherichia coli pathogenicity (2012, neutral): “Once internalized, UPEC can rapidly replicate and form biofilm-like complexes termed intracellular bacterial communities (IBCs) or pods, which serve as transient, protective environment”
The biology and future prospects of antivirulence therapies (2008, neutral): “and initiate a pathogenic cascade that involves several distinct phases as examined in the mouse cystitis mode”
The Acetate Switch (2005, neutral): “, flagella, type 1 pili, and capsule (10).”
Bacterial Biofilms: Development, Dispersal, and Therapeutic Strategies in the Dawn of the Postantibiotic Era (2013, positive): “Although internalized UPEC are expelled in a TLR-4-dependent process (Bishop et al. 2007), some bacteria avoid the exocytic process and escape into the host-cell cytoplasm, where they replicate into IBCs (Anderson et al. 2003; Justice et al. 2004).”
Complicated Catheter-Associated Urinary Tract Infections Due to Escherichia coli and Proteus mirabilis (2008, neutral): “At this stage, pod-like protrusions are observed on the surface of murine bladder epithelial cells (8).”
UroPathogenic Escherichia coli (UPEC) Infections: Virulence Factors, Bladder Responses, Antibiotic, and Non-antibiotic Antimicrobial Strategies (2017, positive): “Replication of internalized UPEC bacteria rapidly occurs, resulting in the maturation of IBCs, a structure that possesses biofilm-like properties which is protected from innate defenses and antibiotics (Justice et al., 2006; Goller and Seed, 2010).”