Bacterial adhesion and entry into host cells.

By J. Pizarro-Cerdá, P. Cossart. Cell, 2006

965 citations recorded by the source corpus.

Successful establishment of infection by bacterial pathogens requires adhesion to host cells, colonization of tissues, and in certain cases, cellular invasion-followed by intracellular multiplication, dissemination to other tissues, or persistence. Bacteria use monomeric adhesins/invasins or highly sophisticated macromolecular machines such as type III secretion systems and retractile type IV pili to establish a complex host/pathogen molecular crosstalk that leads to subversion of cellular functions and establishment of disease.

Subfields: Endocrinology, Genetics, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/5a3f9ca83087524bed1da5d6d3fc4cba701c5572

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology

1. A. McCready-Vangi
2. Elizabeth A. Grice
3. A. Uberoi
4. J. Pizarro-Cerdá
5. D. Monack
6. S. Mariathasan
7. P. Cossart

In Genetics

1. A. McCready-Vangi
2. Elizabeth A. Grice
3. A. Uberoi
4. P. Cossart
5. D. Monack
6. S. Mariathasan

In Infectious Diseases

1. A. McCready-Vangi
2. Elizabeth A. Grice
3. A. Uberoi
4. P. Cossart

Citations in the corpus

• How bacterial pathogens colonize their hosts and invade deeper tissues. (2015, background): “158 Pili, which are polymeric hair-like organelles protruding from the surface of bacteria, 159 represent a first class of structures involved in the binding of bacteria to host cells [30],[31].”
• M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells. (2007, background): “The prevailing paradigm has remained that M. tuberculosis reside in the endocytic system (Orme, 2004; Vergne et al., 2004; Russell et al., 2002; Kang et al., 2005; Russell, 2001; Pizarro-Cerda and Cossart, 2006).”
• Invasive and Adherent Bacterial Pathogens Co-Opt Host Clathrin for Infection (2007, positive): “These bacteria use a specialized secretory apparatus, the type III secretion system (T3SS), to inject bacterial effector proteins into the host cytoplasm to modulate the host actin cytoskeleton, triggering massive polymerization of actin and membrane ruffling, resulting in bacterial internalization ”
• Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation (2007, background): “Invasive bacterial pathogens use specific virulence factors that mediate efficient entry into mammalian cells where they can evade some immune mechanisms, such as complement- and antibody-mediated killing, and establish a replicative nich”
• Als3 Is a Candida albicans Invasin That Binds to Cadherins and Induces Endocytosis by Host Cells (2007, background): “For many microbial pathogens, invasion of host cells is critical for the initiation and maintenance of infection, and many of these organisms have more than one mechanism for inducing their own uptake by host cells [46].”
• The wound microbiota: microbial mechanisms of impaired wound healing and infection (2024, positive): “By themselves, bacteria have a diverse virulence arsenal ranging from surface proteins to appendages (pili or fimbriae) that enables them to adhere to epithelial cells, facilitating colonization and infection 116 .”