Lipoprotein particles are required for Hedgehog and Wingless signalling
By D. Panáková, H. Sprong, Eric Marois, C. Thiele, Suzanne Eaton. Nature, 2005
725 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/18cdf3bdf9dabf16b1a0b7d72276e8a420324908
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
Citations in the corpus
- Extracellular vesicles: Exosomes, microvesicles, and friends (2013, background): “In addition to exosomes or MVs, small lipoprotein particles may also contribute to the secretion and be responsible for tissue gradient formation of Wnt and Hedgehog (Panáková et al., 2005; Eaton, 2006; Neumann et al., 2009).”
- Wnt/beta-catenin signaling in development and disease. (2006, neutral): “Two dedicated, nuclear partners of the TCF/β-catenin complex, Legless/Bcl9 and Pygopus, were recently found in genetic screens in Drosophila (Kramps et al., 2002; Parker et al., 2002; Thompson et al., 2002).”
- Mechanisms and functions of Hedgehog signalling across the metazoa (2011, background): “The assembly of these HH signalling entities is promoted by interaction with lipophorin , an apo-lipoprotein that circulates in the haemolymph of the fl”
- Morphogen gradients: from generation to interpretation. (2011, background): “F or p er so na l u se o nl y. studies suggest that Hh and Wg may be packaged through their lipid modifications into larger-scale lipoprotein particles (Supplemental Figure 4) (Callejo et al. 2008, Eaton 2008, Eugster et al. 2007, Gallet 2011, Panáková et al. 2005).”
- Hedgehog Signaling in Development and Cancer (2008, neutral): “In Drosophila , lipoproteins have been implicated in transporting lipid-modified morphogens including Hh and Wnt/Wg (Panakova et al., 2005).”
- Structural basis of WLS/Evi-mediated Wnt transport and secretion (2020, background): “When Wnt covalent O-acylation was first identified, speculation centered on a membrane-tethering or lipoprotein-binding role for the fatty acid, similar to the role the far more common S-palmitoylation plays in diverse proteins (Panáková et al., 2005; Smotrys and Linder, 2004; Takada et al., 2006; W”
- Wnt/β-catenin signaling and disease. (2012, neutral): “In this context, the Wg protein may act in association with lipoprotein particles (Panáková et al., 2005; Zecca et al., 1996).”
- Mechanisms of intercellular Wnt transport (2019, background): “Analogous results have been seen for Hedgehog (Hh) signalling, another lipid-modified morphogen, which indicates that lipoprotein particles are a common mechanism for long-range morphogen signalling (Panáková et al., 2005).”
- Subcellular targeting strategies for drug design and delivery (2010, background): “Ongoing studies that are trying to exploit cellular machineries for specific delivery are showing promise; these are examining transport in extracellular vehicles such as exosomes and lipoproteins, the crossing of the blood–brain barrier by transcytotic routes and the addition of targeting tags and ”
- Wnt signaling and stem cell control (2008, background): “have also been suggested to have a role in the transport of two lipid-linked morphogens in Drosophila, Wg and Hh (Panakova et al. 2005).”
- Hedgehog: functions and mechanisms. (2008, background): “First, Hh staining of receiving cells displays a punctate pattern (Panakova et al. 2005).”
- Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. (2006, background): “Wnt protein is transported between cells by lipoprotein particles in Drosophila wing imaginal discs (Greco et al., 2001; Panakova et al., 2005), an acylation-dependent trafficking system might be prerequisite for attachment of Wnt proteins to lipoprotein particles for secretion.”