Identification of a factor that links apoptotic cells to phagocytes

By R. Hanayama, Masato Tanaka, K. Miwa, A. Shinohara, A. Iwamatsu, S. Nagata. Nature, 2002

1,421 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/18b820dd4fae85c43780acff52be5148d788c6bc

How researchers see this paper

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In Immunology

1. Arlene H. Sharpe
2. C. Théry
3. G. Dranoff
4. G. Freeman
5. G. Raposo
6. Richard J. Simpson
7. Marina Colombo
8. K. Ravichandran

In Molecular Biology

1. C. Théry
2. G. Raposo
3. Suresh Mathivanan
4. Marina Colombo
5. Hina Kalra
6. Richard J. Simpson
7. G. Drummen
8. David W. Greening

Citations in the corpus

• An Apoptotic 'Eat Me' Signal: Phosphatidylserine Exposure. (2015, background): “Milk fat globule EGF factor 8 (MFG-E8), originally identified in mammary glands, is a 46-kDa glycoprotein expressed in thioglycollate-elicited peritoneal macrophages, tingible body macrophages in the germinal centers of the spleen, and granulocyte macrophage colony-stimulating factor (GM-CSF)-induce”
• A blast from the past: clearance of apoptotic cells regulates immune responses (2002, background): “So, the exposure of PtdSer might be one of several further signals that are required before bound cells are ingeste”
• Apoptosis: controlled demolition at the cellular level (2008, background): “One candidate is milk fat globule–EGF factor-8 protein, a secreted glycoprotein that is produced by activated macrophages, which can bind to aminophospholipids (including PS) and induce cell uptak”
• Engulfment of apoptotic cells: signals for a good meal (2007, background): “Several years ago, Nagata and colleagues identified the milk fat globule EGF factor 8 protein ( MFGE8 ) as a soluble bridging molecule that is secreted by macrophage”
• Apoptotic cells promote their own clearance and immune tolerance through activation of LXR (2009, positive): “These ‘‘eat-me’’ signals are bound by bridging molecules including milk fat globule EGF factor 8 (MFGE8), growth-arrest- specific 6 (GAS6), and complement factor C1q on the surface of apoptotic cells (Botto et al., 1998; Hanayama et al., 2002; Ish- imoto et al., 2000).”
• Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. (2014, background): “…of EVs) is a ligand for αvβ3 and αvβ5 integrins and has been shown to allow capture of apoptotic cells by macrophages expressing these integrins (Hanayama et al. 2002), and possibly also of DC-EVs by DCs (Morelli et al. 2004); however, other PS-binding receptors, such as TIM4 on phagocytes…”
• Membrane vesicles as conveyors of immune responses (2009, background): “In addition, MFGE8 (milk fat globule epidermal growth factor (EGF) factor 8 protein; also known as lactadherin) binds to phosphatidylserine exposed on the surface of apoptotic cells and secreted membrane vesicles through its carboxy-terminal factorV/VIII-like domai”
• TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. (2007, methodology): “Several receptor combinations that participate in the recognition of PS on the surface of apoptotic cells have been identified, including Milk fat globule EGF-factor 8 (MFG-E8) (Hanayama et al., 2002) and Growth arrest- Im specific gene 6 (GAS6) (Scott et al., 2001).”