A blast from the past: clearance of apoptotic cells regulates immune responses

By J. Savill, I. Dransfield, C. Gregory, C. Haslett. Nature reviews. Immunology, 2002

1,736 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/10eab37193176920b6be9eb0f254f1df9e54a2d5

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In Immunology

1. M. Karin
2. S. Fink
3. T. Lawrence
4. V. Nizet
5. M. Bianchi
6. A. Manfredi
7. T. Wyss‐Coray
8. P. Henson

Citations in the corpus

• Inflammatory Resolution: new opportunities for drug discovery (2004, background): “Great progress has been achieved in recent years in the elucidation of the complex mechanisms that are involved in recognition of apoptotic cells (or apoptotic bodies) by phagocytes (at least 10 recognition mechanisms have been identified so far”
• TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity (2010, background): “Recognition of apoptotic cells is an essential component of tissue homeostasis and immune regulation (12).”
• Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. (2006, background): “Importantly, a number of these receptors recognize endogenous ligands, for example the scavenger receptors SR-A and CD36 mediate phagocytosis of apoptotic cells (AC), which is associated with downregulation of macrophage activation (Savill et al., 2002).”
• Directing Transition from Innate to Acquired Immunity: Defining a Role for IL-61 (2005, background): “Any alteration in the apoptotic response may lead to a delay in neutrophil clearance and retention of an activated mononuclear cell population within the affected tissue (30, 44, 45).”
• The Role of Microglia in the Healthy Brain (2011, background): “Contrary to phagocytosis of necrotic cells, phagocytosis of apoptotic cells is highly efficient, prevents the spillover of cellular contents, and elicits anti-inflammatory responses (Savill et al., 2002; Gregory and Pound, 2011).”
• Adipokines in inflammation and metabolic disease (2011, background): “Because phagocytosis of early apoptotic cells promotes an M2-like phenotype in macrophage”
• Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. (2005, positive): “A wide variety of phagocyte (efferocyte) cell-surface receptors and soluble bridging molecules have been implicated in recognition and removal of apoptotic cells (Savill et al., 2002).”
• Molecular and cellular endocrinology (2000, neutral): “The yerba maté intervention recovered the expression of the genes implicated in thermogenesis in BAT (Table 3).”