Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes

By T. Aasen, Á. Raya, M. J. Barrero, E. Garreta, A. Consiglio, Federico Gonzãlez, R. Vassena, J. Bilić, V. Pekarik, G. Tiscornia and 3 more. Nature Biotechnology, 2008

1,462 citations recorded by the source corpus.

Subfields: Molecular Biology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/189a855a9e0eaa138c3c6f4e65bee77820907f4d

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Citations in the corpus

Induced pluripotency: history, mechanisms, and applications. (2010, background): “Similarly, iPSCs have been derived from other somatic cell populations, such as keratinocytes (Aasen et al. 2008; Maherali et al. 2008), neural cells (Eminli et al. 2008; JB Kim et al. 2008), stomach and liver cells (Aoi et al. 2008), and melanocytes (Utikal et al. 2009a), as well as from…”
Reprogramming of human primary somatic cells by OCT4 and chemical compounds. (2010, background): “Keratinocytes also endogenously express KLF4 and cMYC, and can be reprogrammed efficiently using the conventional four TFs or three TFs (without cMYC) (Aasen et al., 2008; Maherali et al., 2008).”
A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. (2010, background): “Indeed, it has been reported that human epithelial cells such as keratinocytes or hair follicle cells reprogram with higher efficiency than fibroblasts (Aasen et al., 2008), for which the authors used a low-serum protocol in order to prevent cell differentiation.”
Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells. (2010, background): “However, recent studies have shown that other human somatic stem cells can be used (Aasen et al., 2008; Eminli et al., 2009; Kim et al., 2009; Ye et al., 2009).”
Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells. (2011, positive): “, 2009), keratinocytes (Aasen et al., 2008), and neural stem cells (Kim et al.”
Nuclear reprogramming to a pluripotent state by three approaches (2010, background): “Human iPS cells were obtained within a year by inducing overexpression of the same combination of factor”
A fresh look at iPS cells. (2009, background): “Notably, iPS cells derived from mouse hepatocytes (Aoi et al., 2008) or human keratinocytes (Aasen et al., 2008) have fewer retroviral integra- ell 137, April 3, 2009 ©2009 Elsevier Inc. 15 tion sites than do iPS cells derived from fibroblasts.”
Risk factors in the development of stem cell therapy (2011, background): “The transformation of an adult somatic cell into a pluripotent stem cell (iPSC) was firstly achieved by inducing a “forced” expression of specific genes [8-14].”
Epigenetic reprogramming and induced pluripotency (2009, methodology): “Moreover, human keratinocytes undergo faster reprogramming than do human fibroblasts (Aasen et al., 2008; Maherali et al., 2008), and one study even observed an increased efficiency over fibroblasts (Aasen et al., 2008), suggesting that keratinocytes have a transcriptional state that is more…”
Parkinson’s Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors (2009, background): “…and human somatic cells to a pluripotent state has been achieved by viral transduction of four transcription factors, OCT4, KLF4, SOX2, and c-MYC (Aasen et al., 2008; Dimos et al., 2008; Hockemeyer et al., 2008; Lowry et al., 2008; Maherali et al., 2008; Nakagawa et al., 2008; Okita et al.,…”