Reprogramming of human primary somatic cells by OCT4 and chemical compounds.

By Saiyong Zhu, Wen-lin Li, Hongyan Zhou, Wanguo Wei, R. Ambasudhan, Tongxiang Lin, Janghwan Kim, Kang Zhang, Sheng Ding. Cell Stem Cell, 2010

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Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming (2011, background): “Consistent with the ability of small molecules with known metabolic targets to modulate the appearance of pluripotent colonies (Zhu et al., 2010), here stimulation of glycolytic flux potentiated reprogramming, whereas oxidative metabolism promotion preserved the somatic cytotype. c-Myc, through its…”
Metabolic Plasticity in Stem Cell Homeostasis and Differentiation (2012, positive): “Promotion of glycolytic metabolism by drugs (Zhu et al., 2010), by hypoxia (Yoshida et al., 2009), through inhibition of the p53 pathway (Bensaad et al., 2006; Krizhanovsky and Lowe, 2009), or via supplementation with glycolytic intermediates augments reprogramming efficiency, while inhibition of…”
Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells. (2015, background): “…fermentation of glucose to lactate (Metallo and Vander Heiden, 2013), was first described in cancer cells by Nobel laureate Otto Heinrich Warburg in 1924 and more recently reported in embryonic and induced pluripo- tent stem cells (Folmes et al., 2011; Panopoulos et al., 2012; Zhu et al., 2010).”