Course of illness, hippocampal function, and hippocampal volume in major depression

By Glenda Macqueen, S. Campbell, Bruce S. McEwen, Kathryn Macdonald, S. Amano, R. Joffe, C. Nahmias, Trevor Young. Proceedings of the National Academy of Sciences of the United States of America, 2003

1,033 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cognitive Neuroscience, Pharmacology

View Paper: https://www.semanticscholar.org/paper/17731f20b94a96e30b3420f67a9152f95e82c190

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Citations in the corpus

COGNITIVE DEFICITS AND FUNCTIONAL OUTCOMES IN MAJOR DEPRESSIVE DISORDER: DETERMINANTS, SUBSTRATES, AND TREATMENT INTERVENTIONS (2013, background): “[32] This decrement in memory parallels results from morphometric studies that have documented volumetric reduction in the hippocampus in MDD with a more pronounced decrease observed during the first several episodes.[32, 34] Current illness severity was the major determinant of performance, as oppo”
Glucocorticoids, depression, and mood disorders: structural remodeling in the brain. (2005, background): “Translational studies of brain changes in major mood and anxiety disorders such as unipolar and bipolar depression and posttraumatic stress disorder are showing that changes in volume of structures such as hippocampus, prefrontal cortex, and amygdala must be considered as part of the neurobiological”
TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment (2008, result): “Similarly, reduction of hippocampal volume has been reported in some studies of human patients with major depression (Bremner et al., 2000; MacQueen et al., 2003) and posttraumatic stress disorder (Gilbertson et al.”
Neuroimaging studies of mood disorder effects on the brain. (2003, background): “A study of first episode patients identified memory impairment on neuropsychological testing but no hippocampal volume loss, whereas multiple episode patients in the same study had both memory impairment and volume loss (MacQueen et al 2003).”
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “decrease in hippocampal volume (approximately 9% on average across all studies) in patients with MDD (Sheline et al., 1996, 1998, 1999, 2003; Shah et al., 1998; Bremner et al., 2000; Mervaala et al., 2000; Steffens et al., 2000; Frodl et al., 2002; MacQueen et al., 2003; Saarelainen et al., 2003; Ve”
Impulsivity as a vulnerability marker for substance-use disorders: review of findings from high-risk research, problem gamblers and genetic association studies. (2008, background): “For example, there is accumulating evidence that increased cortisol levels during periods of depressed mood may have direct effects on hippocampal structure, with progressive cell loss and volume reduction associated with the duration of depression (MacQueen et al., 2003; Sapolsky et al., 1985).”
A computational principle for hippocampal learning and neurogenesis (2005, background): “Neurogenesis is suppressed by adrenal hormones (Gould et al., 1992), and stress (Gould et al., 1998; Lemaire et al., 2000; McEwen and Magarinos, 2001) as well as in depression (Jacobs et al., 2000), which is associated with a loss of hippocampal volume (MacQueen et al., 2003).”
Discovering Endophenotypes for Major Depression (2004, background): “…declarative memory have been associated with number of depressive episodes, stress, hypercortisolemia, and hippocampal volume reduction found in major depression (MacQueen et al, 2002, 2003), thus suggesting that these memory symptoms are rather a consequence than an etiologic factor of depression.”
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms (2008, background): “Correspondingly, structural imaging has demonstrated decreased hippocampal size in patients with major depression, especially those who have suffered multiple episodes (MacQueen et al, 2003).”
Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. (2008, background): “Interestingly, amygdala volume has been reported to increase in the first episode of depression, whereas hippocampal volume is not decreased (MacQueen et al., 2003; Frodl et al., 2003).”
The role of the hippocampus in the pathophysiology of major depression. (2004, neutral): “episodes further suggested that most of the volume loss occurred within the first few episodes.(23) These data are consistent with recent reports that patients with schizophrenia have the greatest volumetric changes in the period shortly after onset of illness.”