SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B.

By Cheng Sun, Fang Zhang, Xinjian Ge, T. Yan, Xingmiao Chen, Xian-zhe Shi, Q. Zhai. Cell Metabolism, 2007

790 citations recorded by the source corpus.

Subfields: Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/16fad533b3aea52e9ea5c7e959ddf364e85a26dc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Geriatrics and Gerontology

1. Johan Auwerx
2. C. Cantó
3. R. Houtkooper
4. Joseph A. Baur
5. R. Wanders
6. D. Sinclair
7. E. Verdin
8. Keir J. Menzies

In Physiology

1. Johan Auwerx
2. C. Cantó
3. R. Houtkooper
4. Joseph A. Baur
5. Ellen E. Blaak
6. R. Wanders
7. G. Goossens
8. S. Kersten

Citations in the corpus

• Calorie restriction-like effects of 30 days of Resveratrol (resVida™) supplementation on energy metabolism and metabolic profile in obese humans (2011, background): “These beneficial effects of resveratrol on metabolism are in concordance with several findings of resveratrol supplementation in animals (Baur et al., 2006; Cantó et al., 2009; Lagouge et al., 2006; Pearson et al., 2008; Sun et al., 2007).”
• The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. (2010, background): “In general, the effects of SIRT1 activation have a tendency to oppose those of IGF on longevity, although in the long term or in insulin-resistant states, they might both favor insulin sensitivity through repression of PTP1b (189).”
• Insulin resistance: Review of the underlying molecular mechanisms (2018, background): “PTP1B has been suggested as a potential therapy for IR (Koren & Fantus, 2007; Ropelle et al., 2006; Sun et al., 2007), and over-”
• Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending lifespan (2008, positive): “In obese mice, resveratrol improves a number of health parameters, including glucose homeostasis, endurance , and survival (Baur et al., 2006; Lagouge et al., 2006; Sun et al., 2007), at least partly due to the increased activity of SIRT1 and AMPK (Baur et al., 2006; Lagouge et al., 2006).”
• Resveratrol and health--a comprehensive review of human clinical trials. (2011, background): “Multiple mechanisms have been proposed to account for the insulin-sensitizing effects of resveratrol, including antiinflammatory effects [55], SIRT1-dependent suppression of protein-tyrosine phosphatase 1B (PTP1B, the phosphatase that acts on the insulin receptor) [56], and prevention of ectopic lip”