Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

By N. Kayagaki, Irma B. Stowe, Bettina L. Lee, K. O’Rourke, Keith Anderson, S. Warming, Trinna L Cuellar, B. Haley, Merone Roose-Girma, Q. Phung and 15 more. Nature, 2015

3,299 citations recorded by the source corpus.

Subfields: Hematology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/16fad23f6e5d14306bdea43f85256c4eef646e93

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. Edward A. Miao
2. S. B. Kovacs
3. T. Kanneganti
4. M. Lamkanfi

In Immunology

1. T. Kanneganti
2. J. Wells
3. Olivier Julien
4. M. Lamkanfi
5. Yaqiu Wang
6. Edward A. Miao
7. F. Shao
8. R. Malireddi

In Molecular Biology

1. T. Kanneganti
2. M. Lamkanfi
3. Edward A. Miao
4. R. Malireddi
5. S. Kesavardhana
6. Yaqiu Wang
7. S. B. Kovacs
8. V. Dixit

Citations in the corpus

• Pulmonary Innate Immune Response Determines the Outcome of Inflammation During Pneumonia and Sepsis-Associated Acute Lung Injury (2020, background): “The CASP11 activation causes pyroptosis via cleaving gasdermin D (GSDMD) into amino-terminal GSDMD (N-GSDMD) and carboxy-terminal GSDMD (CGSDMD) (232, 233).”
• From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways (2021, background): “Pyroptosis is driven by plasma membrane pore formation by activated gasdermin family members; the prototype is gasdermin D (GSDMD) activation by inflammatory caspases, CASP1 and CASP11 (mice) or CASP4/5 (humans) [15,16].”
• Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection (2018, methodology): “NLRP3 activation via potassium efflux as a consequence of membrane pore formation has recently been shown to occur during both pyroptosis and necroptosis (22, 36).”
• Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death. (2017, background): “Furthermore, Gsdmd deficiency blocks IL-1b secretion without affecting its processing by caspase-1 [28,29].”
• GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death (2016, neutral): “Furthermore, it remains to be shown whether several gasdermins might cooperate in pore formation, given that caspase-1-dependent cell death does not solely rely on GSDMD (Kayagaki et al , 2015).”
• Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes (2020, neutral): “Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells.”
• Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy (2022, background): “In typical and atypical pyroptosis pathways, CASP1/4/5/11 has been reported for GSDMD cleavage.(107,108) Under particular circumstances, apoptosis-dependent CASP8 can directly cleave GSDMD, which triggers pyroptosis.”
• The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation (2016, background): “Other mouse ALRs have been shown to interact with ASC, making them potential regulators of inflammasome responses (Brunette et al., 2012), and another human ALR, γ-IFN–inducible protein 16, is considered a putative inflammasome (Kerur et al., 2011).”